| |  Online-Ressource |
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| Verfasst von: | Benning, Louise [VerfasserIn]  |
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| | Bartenschlager, Marie [VerfasserIn] |
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| | Kim, Heeyoung [VerfasserIn] |
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| | Kälble, Florian [VerfasserIn] |
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| | Nußhag, Christian [VerfasserIn] |
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| | Buylaert, Mirabel [VerfasserIn] |
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| | Reichel, Paula [VerfasserIn] |
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| | Schaier, Matthias [VerfasserIn] |
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| | Morath, Christian [VerfasserIn] |
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| | Zeier, Martin [VerfasserIn] |
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| | Schnitzler, Paul [VerfasserIn] |
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| | Bartenschlager, Ralf [VerfasserIn] |
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| | Speer, Claudius [VerfasserIn] |
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| Titel: | Live-virus serum neutralization after bivalent SARS-CoV-2 mRNA vaccination in hemodialysis patients |
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| Verf.angabe: | Louise Benning, Marie Bartenschlager, Heeyoung Kim, Florian Kälble, Christian Nusshag, Mirabel Buylaert, Paula Reichel, Matthias Schaier, Christian Morath, Martin Zeier, Paul Schnitzler, Ralf Bartenschlager, Claudius Speer |
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| E-Jahr: | 2023 |
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| Jahr: | December 2023 |
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| Umfang: | 10 S. |
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| Illustrationen: | Diagramme |
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| Fussnoten: | Online veröffentlicht: 11. Dezember 2023 ; Gesehen am 21.10.2024 |
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| Titel Quelle: | Enthalten in: Journal of medical virology |
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| Ort Quelle: | Bognor Regis [u.a.] : Wiley, 1977 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 95(2023), 12 vom: Dez., Artikel-ID e29303, Seite 1-10 |
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| ISSN Quelle: | 1096-9071 |
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| Abstract: | The development of bivalent booster vaccines addresses the ongoing evolution of the emerging B.1.1.529 (omicron) variant subtypes that are known to escape vaccine-induced neutralizing antibody response. Little is known about the immunogenicity and reactogenicity of bivalent mRNA vaccines in hemodialysis patients with impaired vaccine response. In this prospective, observational cohort study, we analyzed SARS-CoV-2 anti-S1 IgG, surrogate neutralizing antibodies (SNA), and live-virus neutralization against the SARS-CoV-2 wildtype and the BA.5 variant in 42 hemodialysis patients with and without prior SARS-CoV-2 infection before and after an additional fifth bivalent vaccine dose. Anti-S1 IgG and SNA were significantly higher in hemodialysis patients with prior infection than in patients without infection (p < 0.001 and p < 0.01, respectively). In patients without prior infection, both antibody levels increased, and live-virus neutralizing antibodies against the wildtype and the BA.5 variant were correspondingly significantly higher after bivalent booster vaccination (p < 0.001 for both). Conversely, in patients with prior infection, anti-S1 IgG and SNA did not alter significantly, and bivalent booster vaccination did not induce additional humoral immune response against the SARS-CoV-2 wildtype and the BA.5 variant. Thus, bivalent mRNA vaccines might increase humoral responses in hemodialysis patients without prior infection. Larger clinical trials are needed to help guide vaccination strategies in these immunocompromised individuals. |
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| DOI: | doi:10.1002/jmv.29303 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1002/jmv.29303 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.29303 |
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| | DOI: https://doi.org/10.1002/jmv.29303 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | COVID-19 |
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| | hemodialysis |
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| | mRNA vaccines |
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| | SARS-CoV-2 |
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| | vaccination |
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| | variant-adapted vaccines |
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| K10plus-PPN: | 1906355339 |
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| Verknüpfungen: | → Zeitschrift |
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Live-virus serum neutralization after bivalent SARS-CoV-2 mRNA vaccination in hemodialysis patients / Benning, Louise [VerfasserIn]; December 2023 (Online-Ressource)
