Pulmonary function in patients with ANCA-associated vasculitis

• Verfasst von: Dieterich, Johannes [VerfasserIn]
• Verfasst von: Hellmich, Bernhard [VerfasserIn]
• Verfasst von: Mahrhold, Juliane [VerfasserIn]
• Verfasst von: Feng, You-Shan [VerfasserIn]
• Verfasst von: Rai, Abdallah El [VerfasserIn]
• Verfasst von: Nessyt, Felix [VerfasserIn]
• Verfasst von: Specks, Ulrich [VerfasserIn]
• Verfasst von: Hetzel, Jürgen [VerfasserIn]
• Verfasst von: Löffler, Christian [VerfasserIn]
• Titel: Pulmonary function in patients with ANCA-associated vasculitis
• Verf.angabe: Johannes Dieterich, Bernhard Hellmich, Juliane Mahrhold, You-Shan Feng, Abdallah El Rai, Felix Nessyt, Ulrich Specks, Jürgen Hetzel, Christian Löffler
• E-Jahr: 2024
• Jahr: Jun 28, 2024
• Umfang: 1-11$t11
• Fussnoten: Gesehen am 22.10.2024
• Titel Quelle: Enthalten in: Sarcoidosis, vasculitis and diffuse lung diseases
• Ort Quelle: Fidenza : Mattioli, 2008
• Jahr Quelle: 2024
• Band/Heft Quelle: 41(2024), 2, Artikel-ID e2024025
• DOI: doi:10.36141/svdld.v41i2.15577
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1906372136

Abstract

Background and aim: Although pulmonary manifestations occur frequently in ANCA-associated vasculitis (AAV), empirical evidence of their impact on pulmonary function is scarce. This study analyzed pulmonary function test (PFT) data from a large cohort of patients with AVV. Results were correlated with findings from diagnostic imaging and disease activity. Methods: Data from AAV patients with PFTs performed between 2008 and 2018 were extracted retrospectively from the database of a tertiary vasculitis center. Demographic and disease characteristics, imaging data and follow-up results were assessed and compared to PFT results. Results: The final analysis encompassed 147 patients. The mean time between first PFT and follow-up was 7.0 ± 11.0 months. In Granulomatosis with Polyangiitis (GPA), forced expiratory vital capacity (FVCex, p<0.001), residual volume (RV, p<0.001) and the diffusion capacity of carbon oxide (TLCO, p=0.003) were significantly reduced compared to the reference value of 100% predicted. There was no significant difference between patients with or without pulmonary manifestations. In Microscopic Polyangiitis (MPA), reductions of FVCex (p<0.001), TLC (p=0.005), and TLCO (p=0.003) were observed. In Eosinophilic Granulomatosis with Polyangiitis (EGPA), total airway resistance (RAWtot, p=0.024) and RV (p=0.009) were significantly elevated and TLCO was reduced (p=0.014). Interstitial lung disease (ILD) is associated with a decline of FVCex (-15.7%, p=0.0028), TLC (-26.5%, p<0.001), RV (-38.9%, p=0.023) and TLCO (-29.1%, p=0.007). Significant differences were neither detected between first PFT and follow-up examination, nor between patients with active versus inactive disease. Conclusions: AAV patients presented with characteristic alterations in PFTs according to their respective pulmonary and/or airway manifestations. These results did not change over time and were independent from vasculitis activity.