Cardiac sympathetic nervous activity during myocardial ischemia, reperfusion and ventricular fibrillation in the dog

• Verfasst von: Aidonidis, Isaac [VerfasserIn]
• Verfasst von: Brachmann, Johannes [VerfasserIn]
• Verfasst von: Seller, Horst [VerfasserIn]
• Verfasst von: Dembowsky, Klaus [VerfasserIn]
• Verfasst von: Czachurski, Jürgen [VerfasserIn]
• Verfasst von: Kübler, Wolfgang [VerfasserIn]
• Titel: Cardiac sympathetic nervous activity during myocardial ischemia, reperfusion and ventricular fibrillation in the dog
• Titelzusatz: effects of intravenous lidocaine
• Verf.angabe: Isaac Aidonidis, Johannes Brachmann, Horst Seller, Klaus Dembowsky, Jürgen Czachurski, Wolfgang Kübler
• Jahr: 1992
• Umfang: 9 S.
• Fussnoten: Elektronische Reproduktion der Druck-Ausgabe 12. November 2008 ; Gesehen am 22.10.2024
• Titel Quelle: Enthalten in: Cardiology
• Ort Quelle: Basel : Karger, 1970
• Jahr Quelle: 2008
• Band/Heft Quelle: 80(2008), 3-4, Seite 196-204
• ISSN Quelle: 1421-9751
• DOI: doi:10.1159/000175003
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1906418888

Abstract

In 12 open-chest dogs, cardiac sympathetic nervous activity (CSNA) was recorded before and after occlusion of the left anterior descending coronary artery as well as during reperfusion and ventricular fibrillation (VF). In 7 control animals, CSNA did not significantly differ from preocclusion levels when determined 20 min after occlusion (+3.5 ± 1.5%, mean ± SEM) and up to 15 min following reperfusion (+1.5 ± 0.6%). However, VF was associated with a potential increase in CSNA by 106 ± 15.5%(p < 0.001). The effect of lidocaine (6 mg/kg) on cardiac sympathetic tone was examined in 5 additional animals. Lidocaine reduced control CSNA by 23 ± 4.7% (p < 0.001); subsequent ischemia and reperfusion did not substantially change the level of preocclusion activity. CSNA decreased significantly also during VF (52 ± 4.2%, p < 0.001). In conclusion, efferent CSNA was slightly altered in the course of acute myocardial ischemia and reperfusion, but significantly increased during VF. Lidocaine produced marked attenuation of CSNA in anesthetized dogs.