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Status: Bibliographieeintrag

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Verfasst von:Rühl, Heiko [VerfasserIn]   i
 Bode, Christian [VerfasserIn]   i
 Becher, Tobias [VerfasserIn]   i
 Eckert, Sebastian [VerfasserIn]   i
 Mohsen, Ghaith [VerfasserIn]   i
 McRae, Hannah L. [VerfasserIn]   i
 Müller, Jens [VerfasserIn]   i
 Reda, Sara [VerfasserIn]   i
 Loßnitzer, Dirk [VerfasserIn]   i
 Oldenburg, Johannes [VerfasserIn]   i
 Putensen, Christian [VerfasserIn]   i
 Pötzsch, Bernd [VerfasserIn]   i
Titel:Decreased protein C pathway activity in COVID-19 compared to non-COVID sepsis
Titelzusatz:an observational and comparative cohort study
Verf.angabe:Heiko Rühl, Christian Bode, Tobias Becher, Sebastian Eckert, Ghaith Mohsen, Hannah L. McRae, Jens Müller, Sara Reda, Dirk Loßnitzer, Johannes Oldenburg, Christian Putensen and Bernd Pötzsch
E-Jahr:2024
Jahr:2 September 2024
Umfang:12 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 23.10.2024
Titel Quelle:Enthalten in: Biomedicines
Ort Quelle:Basel : MDPI, 2013
Jahr Quelle:2024
Band/Heft Quelle:12(2024), 9, Artikel-ID 1982, Seite 1-12
ISSN Quelle:2227-9059
Abstract:Sepsis-associated coagulopathy increases risk of mortality. Impairment of the anticoagulant protein C (PC) pathway may contribute to the thrombotic phenotype in coronavirus disease 2019 (COVID-19) sepsis. This study assessed the functionality of this pathway in COVID-19 and non-COVID sepsis by measuring its key enzymes, thrombin and activated PC (APC). The study population included 30 patients with COVID-19, 47 patients with non-COVID sepsis, and 40 healthy controls. In healthy controls, coagulation activation and subsequent APC formation was induced by 15 µg/kg recombinant activated factor VII one hour before blood sampling. APC and thrombin in plasma were measured using oligonucleotide-based enzyme capture assays. The indirect thrombin markers prothrombin-fragment 1+2 (F1+2) and thrombin-antithrombin complex (TAT) were also measured. Compared with stimulated healthy controls, median thrombin, F1+2, and TAT levels were higher in patients with COVID-19 (up to 6-fold, p < 2 × 10−6) and non-COVID sepsis (up to 4.7-fold, p < 0.010). APC levels were 2.4-fold higher in patients with COVID-19 (7.44 pmol/L, p = 0.011) and 3.4-fold higher in non-COVID sepsis patients (10.45 pmol/L, p = 2 × 10−4) than in controls (3.08 pmol/L). Thrombin markers and APC showed correlation in both COVID-19 (r = 0.364-0.661) and non-COVID sepsis patients (r = 0.535-0.711). After adjustment for PC levels, median APC/thrombin, APC/F1+2, and APC/TAT ratios were 2-fold (p = 0.036), 6-fold (p = 3 × 10−7) and 3-fold (p = 8 × 10−4) lower in the COVID-19 group than in the non-COVID sepsis group, and the latter two were also lower in the COVID-19 group than in stimulated healthy controls. In conclusion, it was found that a comparatively lower anticoagulant APC response in COVID-19 patients as compared to non-COVID sepsis patients, potentially linked to endothelial dysfunction, contributes to the prothrombotic phenotype of COVID-19 sepsis.
DOI:doi:10.3390/biomedicines12091982
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.3390/biomedicines12091982
 Volltext: https://www.mdpi.com/2227-9059/12/9/1982
 DOI: https://doi.org/10.3390/biomedicines12091982
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:COVID-19
 protein C
 sepsis
 thrombin
 thrombophilia
K10plus-PPN:1906636311
Verknüpfungen:→ Zeitschrift

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