| Online-Ressource |
Verfasst von: | Reinhardt, Marielen [VerfasserIn]  |
| Schupp, Tobias [VerfasserIn]  |
| Behnes, Michael [VerfasserIn]  |
| Lau, Felix [VerfasserIn]  |
| Schmitt, Alexander [VerfasserIn]  |
| Abel, Noah [VerfasserIn]  |
| Akın, Muharrem [VerfasserIn]  |
| Rusnak, Jonas [VerfasserIn]  |
| Akın, Ibrahim [VerfasserIn]  |
| Weidner, Kathrin [VerfasserIn]  |
Titel: | Age-related outcomes in heart failure with mildly reduced ejection fraction |
Verf.angabe: | Marielen Reinhardt, Tobias Schupp, Michael Behnes, Felix Lau, Alexander Schmitt, Noah Abel, Muharrem Akin, Jonas Rusnak, Ibrahim Akin and Kathrin Weidner |
E-Jahr: | 2024 |
Jahr: | 30 August 2024 |
Umfang: | 18 S. |
Illustrationen: | Illustrationen |
Fussnoten: | Gesehen am 23.10.2024 |
Titel Quelle: | Enthalten in: Journal of Clinical Medicine |
Ort Quelle: | Basel : MDPI, 2012 |
Jahr Quelle: | 2024 |
Band/Heft Quelle: | 13(2024), 17, Artikel-ID 5151, Seite 1-18 |
ISSN Quelle: | 2077-0383 |
Abstract: | Objective: This study investigates age-related differences and outcomes in patients hospitalized with heart failure with a mildly reduced ejection fraction (HFmrEF). Background: The characterization of patients with HFmrEF and the prognostic value of age has rarely been investigated. Methods: Patients with HFmrEF were retrospectively included at one institution between 2016 and 2022. The distribution of HF aetiology and prognostic outcomes were investigated comparing patients with ≤40, >40 to ≤60, >60 to ≤80, and >80 years of age. The primary endpoint was long-term all-cause mortality. Kaplan-Meier and multivariable Cox proportional regression analyses were applied for statistics. Results: For the present study, 2184 patients with HFmrEF with a median age of 76 years were included. Non-ischemic cardiomyopathy was the most common HF aetiology in patients <40 years of age, whereas patients with 60-80 years of age (60.2%) and >80 years of age (58.2%) had the higher rates of ischemic cardiomyopathies. The risk of long-term all-cause mortality at 30 months was highest in patients with >80 years of age (HR = 2.167; 95% CI 1.928-2.436; p = 0.001), even after multivariable adjustment. Furthermore, patients with >80 years of age had the highest risk of HF-related rehospitalization (HR = 1.529; 95% CI 1.293-1.807; p = 0.001). Conclusions: Ischemic cardiomyopathy represents the most common cause of HF in elderly patients with HFmrEF, whereas younger patients were more likely to suffer from non-ischemic HF aetiologies. Increasing age was an independent predictor of long-term all-cause mortality in patients hospitalized with HFmrEF. |
DOI: | doi:10.3390/jcm13175151 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/jcm13175151 |
| kostenfrei: Volltext: https://www.mdpi.com/2077-0383/13/17/5151 |
| DOI: https://doi.org/10.3390/jcm13175151 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | age |
| ejection fraction |
| elderly |
| heart failure |
| HFmrEF |
| mortality |
K10plus-PPN: | 1906637466 |
Verknüpfungen: | → Zeitschrift |
Age-related outcomes in heart failure with mildly reduced ejection fraction / Reinhardt, Marielen [VerfasserIn]; 30 August 2024 (Online-Ressource)