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Verfasst von:Reinhardt, Marielen [VerfasserIn]   i
 Schupp, Tobias [VerfasserIn]   i
 Behnes, Michael [VerfasserIn]   i
 Lau, Felix [VerfasserIn]   i
 Schmitt, Alexander [VerfasserIn]   i
 Abel, Noah [VerfasserIn]   i
 Akın, Muharrem [VerfasserIn]   i
 Rusnak, Jonas [VerfasserIn]   i
 Akın, Ibrahim [VerfasserIn]   i
 Weidner, Kathrin [VerfasserIn]   i
Titel:Age-related outcomes in heart failure with mildly reduced ejection fraction
Verf.angabe:Marielen Reinhardt, Tobias Schupp, Michael Behnes, Felix Lau, Alexander Schmitt, Noah Abel, Muharrem Akin, Jonas Rusnak, Ibrahim Akin and Kathrin Weidner
E-Jahr:2024
Jahr:30 August 2024
Umfang:18 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 23.10.2024
Titel Quelle:Enthalten in: Journal of Clinical Medicine
Ort Quelle:Basel : MDPI, 2012
Jahr Quelle:2024
Band/Heft Quelle:13(2024), 17, Artikel-ID 5151, Seite 1-18
ISSN Quelle:2077-0383
Abstract:Objective: This study investigates age-related differences and outcomes in patients hospitalized with heart failure with a mildly reduced ejection fraction (HFmrEF). Background: The characterization of patients with HFmrEF and the prognostic value of age has rarely been investigated. Methods: Patients with HFmrEF were retrospectively included at one institution between 2016 and 2022. The distribution of HF aetiology and prognostic outcomes were investigated comparing patients with ≤40, >40 to ≤60, >60 to ≤80, and >80 years of age. The primary endpoint was long-term all-cause mortality. Kaplan-Meier and multivariable Cox proportional regression analyses were applied for statistics. Results: For the present study, 2184 patients with HFmrEF with a median age of 76 years were included. Non-ischemic cardiomyopathy was the most common HF aetiology in patients <40 years of age, whereas patients with 60-80 years of age (60.2%) and >80 years of age (58.2%) had the higher rates of ischemic cardiomyopathies. The risk of long-term all-cause mortality at 30 months was highest in patients with >80 years of age (HR = 2.167; 95% CI 1.928-2.436; p = 0.001), even after multivariable adjustment. Furthermore, patients with >80 years of age had the highest risk of HF-related rehospitalization (HR = 1.529; 95% CI 1.293-1.807; p = 0.001). Conclusions: Ischemic cardiomyopathy represents the most common cause of HF in elderly patients with HFmrEF, whereas younger patients were more likely to suffer from non-ischemic HF aetiologies. Increasing age was an independent predictor of long-term all-cause mortality in patients hospitalized with HFmrEF.
DOI:doi:10.3390/jcm13175151
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.3390/jcm13175151
 kostenfrei: Volltext: https://www.mdpi.com/2077-0383/13/17/5151
 DOI: https://doi.org/10.3390/jcm13175151
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:age
 ejection fraction
 elderly
 heart failure
 HFmrEF
 mortality
K10plus-PPN:1906637466
Verknüpfungen:→ Zeitschrift

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