Age-related outcomes in heart failure with mildly reduced ejection fraction

• Verfasst von: Reinhardt, Marielen [VerfasserIn]
• Verfasst von: Schupp, Tobias [VerfasserIn]
• Verfasst von: Behnes, Michael [VerfasserIn]
• Verfasst von: Lau, Felix [VerfasserIn]
• Verfasst von: Schmitt, Alexander [VerfasserIn]
• Verfasst von: Abel, Noah [VerfasserIn]
• Verfasst von: Akın, Muharrem [VerfasserIn]
• Verfasst von: Rusnak, Jonas [VerfasserIn]
• Verfasst von: Akın, Ibrahim [VerfasserIn]
• Verfasst von: Weidner, Kathrin [VerfasserIn]
• Titel: Age-related outcomes in heart failure with mildly reduced ejection fraction
• Verf.angabe: Marielen Reinhardt, Tobias Schupp, Michael Behnes, Felix Lau, Alexander Schmitt, Noah Abel, Muharrem Akin, Jonas Rusnak, Ibrahim Akin and Kathrin Weidner
• E-Jahr: 2024
• Jahr: 30 August 2024
• Umfang: 18 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 23.10.2024
• Titel Quelle: Enthalten in: Journal of Clinical Medicine
• Ort Quelle: Basel : MDPI, 2012
• Jahr Quelle: 2024
• Band/Heft Quelle: 13(2024), 17, Artikel-ID 5151, Seite 1-18
• ISSN Quelle: 2077-0383
• DOI: doi:10.3390/jcm13175151
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: age
• Sach-SW: ejection fraction
• Sach-SW: elderly
• Sach-SW: heart failure
• Sach-SW: HFmrEF
• Sach-SW: mortality
• K10plus-PPN: 1906637466

Abstract

Objective: This study investigates age-related differences and outcomes in patients hospitalized with heart failure with a mildly reduced ejection fraction (HFmrEF). Background: The characterization of patients with HFmrEF and the prognostic value of age has rarely been investigated. Methods: Patients with HFmrEF were retrospectively included at one institution between 2016 and 2022. The distribution of HF aetiology and prognostic outcomes were investigated comparing patients with ≤40, >40 to ≤60, >60 to ≤80, and >80 years of age. The primary endpoint was long-term all-cause mortality. Kaplan-Meier and multivariable Cox proportional regression analyses were applied for statistics. Results: For the present study, 2184 patients with HFmrEF with a median age of 76 years were included. Non-ischemic cardiomyopathy was the most common HF aetiology in patients <40 years of age, whereas patients with 60-80 years of age (60.2%) and >80 years of age (58.2%) had the higher rates of ischemic cardiomyopathies. The risk of long-term all-cause mortality at 30 months was highest in patients with >80 years of age (HR = 2.167; 95% CI 1.928-2.436; p = 0.001), even after multivariable adjustment. Furthermore, patients with >80 years of age had the highest risk of HF-related rehospitalization (HR = 1.529; 95% CI 1.293-1.807; p = 0.001). Conclusions: Ischemic cardiomyopathy represents the most common cause of HF in elderly patients with HFmrEF, whereas younger patients were more likely to suffer from non-ischemic HF aetiologies. Increasing age was an independent predictor of long-term all-cause mortality in patients hospitalized with HFmrEF.