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| Verfasst von: | Polonsky, Michal [VerfasserIn]  |
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| | Gerhardt, Louisa Maria Sophie [VerfasserIn] |
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| | Yun, Jina [VerfasserIn] |
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| | Koppitch, Kari [VerfasserIn] |
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| | Colón, Katsuya Lex [VerfasserIn] |
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| | Amrhein, Henry [VerfasserIn] |
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| | Wold, Barbara [VerfasserIn] |
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| | Zheng, Shiwei [VerfasserIn] |
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| | Yuan, Guo-Cheng [VerfasserIn] |
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| | Thomson, Matt [VerfasserIn] |
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| | Cai, Long [VerfasserIn] |
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| | McMahon, Andrew P. [VerfasserIn] |
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| Titel: | Spatial transcriptomics defines injury specific microenvironments and cellular interactions in kidney regeneration and disease |
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| Verf.angabe: | Michal Polonsky, Louisa M.S. Gerhardt, Jina Yun, Kari Koppitch, Katsuya Lex Colón, Henry Amrhein, Barbara Wold, Shiwei Zheng, Guo-Cheng Yuan, Matt Thomson, Long Cai & Andrew P. McMahon |
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| E-Jahr: | 2024 |
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| Jahr: | 5. September 2024 |
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| Umfang: | 16 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 24.10.2024 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Springer Nature, 2010 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 15(2024), Artikel-ID 7010, Seite 1-16 |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | Kidney injury disrupts the intricate renal architecture and triggers limited regeneration, together with injury-invoked inflammation and fibrosis. Deciphering the molecular pathways and cellular interactions driving these processes is challenging due to the complex tissue structure. Here, we apply single cell spatial transcriptomics to examine ischemia-reperfusion injury in the mouse kidney. Spatial transcriptomics reveals injury-specific and spatially-dependent gene expression patterns in distinct cellular microenvironments within the kidney and predicts Clcf1-Crfl1 in a molecular interplay between persistently injured proximal tubule cells and their neighboring fibroblasts. Immune cell types play a critical role in organ repair. Spatial analysis identifies cellular microenvironments resembling early tertiary lymphoid structures and associated molecular pathways. Collectively, this study supports a focus on molecular interactions in cellular microenvironments to enhance understanding of injury, repair and disease. |
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| DOI: | doi:10.1038/s41467-024-51186-z |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1038/s41467-024-51186-z |
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| | kostenfrei: Volltext: https://www.nature.com/articles/s41467-024-51186-z |
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| | DOI: https://doi.org/10.1038/s41467-024-51186-z |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cellular signalling networks |
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| | Mechanisms of disease |
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| | Transcriptomics |
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| K10plus-PPN: | 1906728038 |
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| Verknüpfungen: | → Zeitschrift |
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Spatial transcriptomics defines injury specific microenvironments and cellular interactions in kidney regeneration and disease / Polonsky, Michal [VerfasserIn]; 5. September 2024 (Online-Ressource)
