| |  Online-Ressource |
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| Verfasst von: | Kuzmina, Alona [VerfasserIn]  |
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| | Sadhu, Lopamudra [VerfasserIn] |
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| | Hasanuzzaman, Md [VerfasserIn] |
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| | Fujinaga, Koh [VerfasserIn] |
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| | Schwartz, Jacob C. [VerfasserIn] |
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| | Fackler, Oliver Till [VerfasserIn] |
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| | Taube, Ran [VerfasserIn] |
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| Titel: | Direct and indirect effects of CYTOR lncRNA regulate HIV gene expression |
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| Verf.angabe: | Alona Kuzmina, Lopamudra Sadhu, Md Hasanuzzaman, Koh Fujinaga, Jacob C. Schwartz, Oliver T. Fackler, Ran Taube |
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| E-Jahr: | 2024 |
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| Jahr: | April 25, 2024 |
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| Umfang: | 22 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 25.10.2024 |
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| Titel Quelle: | Enthalten in: Public Library of SciencePLoS pathogens |
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| Ort Quelle: | Lawrence, Kan. : PLoS, 2005 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 20(2024), 4, Artikel-ID e1012172, Seite 1-22 |
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| ISSN Quelle: | 1553-7374 |
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| Abstract: | The implementation of antiretroviral therapy (ART) has effectively restricted the transmission of Human Immunodeficiency Virus (HIV) and improved overall clinical outcomes. However, a complete cure for HIV remains out of reach, as the virus persists in a stable pool of infected cell reservoir that is resistant to therapy and thus a main barrier towards complete elimination of viral infection. While the mechanisms by which host proteins govern viral gene expression and latency are well-studied, the emerging regulatory functions of non-coding RNAs (ncRNA) in the context of T cell activation, HIV gene expression and viral latency have not yet been thoroughly explored. Here, we report the identification of the Cytoskeleton Regulator (CYTOR) long non-coding RNA (lncRNA) as an activator of HIV gene expression that is upregulated following T cell stimulation. Functional studies show that CYTOR suppresses viral latency by directly binding to the HIV promoter and associating with the cellular positive transcription elongation factor (P-TEFb) to activate viral gene expression. CYTOR also plays a global role in regulating cellular gene expression, including those involved in controlling actin dynamics. Depletion of CYTOR expression reduces cytoplasmic actin polymerization in response to T cell activation. In addition, treating HIV-infected cells with pharmacological inhibitors of actin polymerization reduces HIV gene expression. We conclude that both direct and indirect effects of CYTOR regulate HIV gene expression. |
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| DOI: | doi:10.1371/journal.ppat.1012172 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1371/journal.ppat.1012172 |
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| | kostenfrei: Volltext: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1012172 |
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| | DOI: https://doi.org/10.1371/journal.ppat.1012172 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Actin polymerization |
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| | Actins |
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| | Gene expression |
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| | Gene regulation |
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| | HIV |
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| | Long non-coding RNA |
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| | Non-coding RNA |
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| | T helper cells |
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| K10plus-PPN: | 1906822891 |
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| Verknüpfungen: | → Zeitschrift |
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Direct and indirect effects of CYTOR lncRNA regulate HIV gene expression / Kuzmina, Alona [VerfasserIn]; April 25, 2024 (Online-Ressource)
