Status: Bibliographieeintrag
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| |  Online-Ressource |
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| Verfasst von: | Tony-Odigie, Andrew [VerfasserIn]  |
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| | Dalpke, Alexander [VerfasserIn] |
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| | Boutin, Sébastien [VerfasserIn] |
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| | Yi, Buqing [VerfasserIn] |
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| Titel: | Airway commensal bacteria in cystic fibrosis inhibit the growth of P. aeruginosa via a released metabolite |
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| Verf.angabe: | Andrew Tony-Odigie, Alexander H. Dalpke, Sébastien Boutin, Buqing Yi |
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| E-Jahr: | 2024 |
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| Jahr: | 9 March 2024 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 28.10.2024 |
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| Titel Quelle: | Enthalten in: Microbiological research |
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| Ort Quelle: | Jena : Urban & Fischer, 1994 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 283(2024), Artikel-ID 127680, Seite 127680-1-127680-11 |
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| ISSN Quelle: | 1618-0623 |
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| Abstract: | In cystic fibrosis (CF), Pseudomonas aeruginosa infection plays a critical role in disease progression. Although multiple studies suggest that airway commensals might be able to interfere with pathogenic bacteria, the role of the distinct commensals in the polymicrobial lung infections is largely unknown. In this study, we aimed to identify airway commensal bacteria that may inhibit the growth of P. aeruginosa. Through a screening study with more than 80 CF commensal strains across 21 species, more than 30 commensal strains from various species have been identified to be able to inhibit the growth of P. aeruginosa. The underlying mechanisms were investigated via genomic, metabolic and functional analysis, revealing that the inhibitory commensals may affect the growth of P. aeruginosa by releasing a large amount of acetic acid. The data provide information about the distinct roles of airway commensals and provide insights into novel strategies for controlling airway infections. |
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| DOI: | doi:10.1016/j.micres.2024.127680 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.micres.2024.127680 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0944501324000818 |
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| | DOI: https://doi.org/10.1016/j.micres.2024.127680 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Airway microbiome |
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| | Commensal-Pathogen interaction |
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| | Cystic fibrosis |
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| | Growth inhibition |
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| | Infection control |
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| | Respiratory infection |
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| K10plus-PPN: | 1907028471 |
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| Verknüpfungen: | → Zeitschrift |
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Airway commensal bacteria in cystic fibrosis inhibit the growth of P. aeruginosa via a released metabolite / Tony-Odigie, Andrew [VerfasserIn]; 9 March 2024 (Online-Ressource)
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