| |  Online-Ressource |
|---|
| Verfasst von: | Loghmani, Seyed Babak [VerfasserIn]  |
|---|
| | Zitzow, Eric [VerfasserIn] |
|---|
| | Schwarzmüller, Luisa [VerfasserIn] |
|---|
| | Humboldt, Yvonne [VerfasserIn] |
|---|
| | Eisenberg, Philip [VerfasserIn] |
|---|
| | Kreikemeyer, Bernd [VerfasserIn] |
|---|
| | Veith, Nadine [VerfasserIn] |
|---|
| | Kummer, Ursula [VerfasserIn] |
|---|
| | Fiedler, Tomas [VerfasserIn] |
|---|
| Titel: | Comparing genome-scale metabolic models of the non-resistant Enterococcus faecalis ATCC 19433 and the multi-resistant Enterococcus faecalis V583 |
|---|
| Verf.angabe: | Seyed Babak Loghmani, Eric Zitzow, Luisa Schwarzmüller, Yvonne Humboldt, Philip Eisenberg, Bernd Kreikemeyer, Nadine Veith, Ursula Kummer, Tomas Fiedler |
|---|
| E-Jahr: | 2024 |
|---|
| Jahr: | 10 September 2024 |
|---|
| Umfang: | 9 S. |
|---|
| Illustrationen: | Illustrationen |
|---|
| Fussnoten: | Online verfügbar: 10. Juli 2024, Artikelversion: 14. Juli 2024 ; Gesehen am 29.10.2024 |
|---|
| Titel Quelle: | Enthalten in: Journal of biotechnology |
|---|
| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1984 |
|---|
| Jahr Quelle: | 2024 |
|---|
| Band/Heft Quelle: | 392(2024), Seite 109-117 |
|---|
| ISSN Quelle: | 1873-4863 |
|---|
| Abstract: | Enterococcus faecalis is a versatile lactic acid bacterium with a large variety of implications for humans. While some strains of this species are pathobionts being resistant against most of the common antibiotics, other strains are regarded as biological protectants or even probiotics. Accordingly, E. faecalis strains largely differ in the size and content of their accessory genome. In this study, we describe the genome-scale metabolic network reconstruction of E. faecalis ATCC 19433, a non-resistant human-associated strain. A comparison of the genome-scale metabolic model (GSM) of E. faecalis ATCC 19433 with a previously published GSM of the multi-resistant pathobiontic E. faecalis V583 reveals high similarities in the central metabolic abilities of these two human associated strains. This is reflected, e.g., in the identical amino acid auxotrophies. The ATCC 19433 strain, however, has a 14.1% smaller genome than V583 and lacks the multiple antibiotic resistance genes and genes involved in capsule formation. Based on the measured metabolic fluxes at different growth rates, the energy demand at zero growth was calculated to be about 40% lower for the ATCC 19433 strain compared to V583. Furthermore, the ATCC 19433 strain seems less prone to the depletion of amino acids utilizable for energy metabolism. This might hint at a lower overall energy demand of the ATCC 19433 strain as compared to V583. |
|---|
| DOI: | doi:10.1016/j.jbiotec.2024.07.006 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.jbiotec.2024.07.006 |
|---|
| | Volltext: https://www.sciencedirect.com/science/article/pii/S0168165624001925 |
|---|
| | DOI: https://doi.org/10.1016/j.jbiotec.2024.07.006 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Amino acid auxotrophies |
|---|
| | Energy demand |
|---|
| | Genome-scale metabolic model |
|---|
| K10plus-PPN: | 1907060243 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Comparing genome-scale metabolic models of the non-resistant Enterococcus faecalis ATCC 19433 and the multi-resistant Enterococcus faecalis V583 / Loghmani, Seyed Babak [VerfasserIn]; 10 September 2024 (Online-Ressource)
