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Verfasst von:Zhang, Xiaotan [VerfasserIn]   i
 Wang, Guang [VerfasserIn]   i
 Li, Ming [VerfasserIn]   i
 Li, Yunjin [VerfasserIn]   i
 Luo, Xin [VerfasserIn]   i
 Liu, Yvonne [VerfasserIn]   i
 Zhang, Xiaoli [VerfasserIn]   i
 Hocher, Johann-Georg [VerfasserIn]   i
 Krämer, Bernhard [VerfasserIn]   i
 Hocher, Berthold [VerfasserIn]   i
 Yang, Xuesong [VerfasserIn]   i
Titel:Both partial inactivation as well as activation of NF-κB signaling lead to hypertension and chronic kidney disease
Verf.angabe:Xiaotan Zhang, Guang Wang, Ming Li, Yunjin Li, Xin Luo, Yvonne Liu, Xiaoli Zhang, Johann-Georg Hocher, Bernhard K Krämer, Berthold Hocher and Xuesong Yang
Jahr:2024
Umfang:12 S.
Illustrationen:Illustrationen
Fussnoten:Im Titel ist "NF-κB " mit einem griechischen Buchstaben geschrieben ; Online vorab veröffentlicht: 13. April 2024 ; Gesehen am 29.10.2024
Titel Quelle:Enthalten in: Nephrology, dialysis, transplantation
Ort Quelle:Oxford : Oxford Univ. Press, 1986
Jahr Quelle:2024
Band/Heft Quelle:39(2024), 12, Seite 1993-2004
ISSN Quelle:1460-2385
Abstract:Activation of nuclear factor-kappa B (NF-κB) signalling is key in the pathogenesis of chronic kidney disease (CKD). However, a certain level of NF-κB activity is necessary to enable tissue repair.The relationship between activated and inactivated NF-κB signaling and the pathogenesis of CKD was investigated using mouse models of NF-κB partial inactivation (mutating cysteine at position 59 of the sixth exon on the NF-κB gene into alanine) and activation (mutating cysteine at position 59 of the sixth exon on the NF-κB gene into serine).The density of CD3, CD8, CD68 positive cells, as well as the expression of interleukin 6, Tumor necrosis factor receptor associated factor 1 and Nef-associated factor 1 in the kidney tissues of NF-κBC59A mice were reduced, whereas an opposing pattern was observed in the NF-κBC59S mice. Blood pressure, kidney fibrosis (analyzed by periodic acid-Schiff, Masson trichrome and Sirius Red staining, as well as α-SMA immunofluorescence), serum creatinine and urinary albumin-to-creatinine ratio are markedly increased in NF-κB-activated and -inactivated mice compared with controls. Transmission electron microscopy indicated that the glomerular basement membrane was thicker in both NF-κBC59A and NF-κBC59S mice compared with wild-type mice.Using mice models with partially activated and inactivated NF-κB pathways suggests that there is an apparently U-shaped relationship between blood pressure, kidney function as well as morphology and the activation of the NF-κB pathway. A certain optimal activity of the NF-κB pathway seems to be important to maintain optimal kidney function and morphology.
DOI:doi:10.1093/ndt/gfae090
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1093/ndt/gfae090
 Volltext: https://academic.oup.com/ndt/advance-article/doi/10.1093/ndt/gfae090/7645469?login=true
 DOI: https://doi.org/10.1093/ndt/gfae090
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:190709847X
Verknüpfungen:→ Zeitschrift

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