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| Verfasst von: | Cirrincione, Anthony [VerfasserIn]  |
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| | Poos, Alexandra [VerfasserIn] |
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| | Ziccheddu, Bachisio [VerfasserIn] |
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| | Kaddoura, Marcella [VerfasserIn] |
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| | Bärtsch, Marc-Andrea [VerfasserIn] |
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| | Maclachlan, Kylee [VerfasserIn] |
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| | Chojnacka, Monika [VerfasserIn] |
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| | Diamond, Benjamin [VerfasserIn] |
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| | John, Lukas [VerfasserIn] |
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| | Reichert, Philipp [VerfasserIn] |
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| | Huhn, Stefanie [VerfasserIn] |
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| | Blaney, Patrick [VerfasserIn] |
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| | Gagler, Dylan [VerfasserIn] |
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| | Rippe, Karsten [VerfasserIn] |
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| | Zhang, Yanming [VerfasserIn] |
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| | Dogan, Ahmet [VerfasserIn] |
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| | Lesokhin, Alexander M. [VerfasserIn] |
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| | Davies, Faith [VerfasserIn] |
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| | Goldschmidt, Hartmut [VerfasserIn] |
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| | Fenk, Roland [VerfasserIn] |
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| | Weisel, Katja C. [VerfasserIn] |
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| | Mai, Elias K. [VerfasserIn] |
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| | Korde, Neha [VerfasserIn] |
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| | Morgan, Gareth J. [VerfasserIn] |
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| | Usmani, Saad [VerfasserIn] |
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| | Landgren, Ola [VerfasserIn] |
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| | Raab, Marc-Steffen [VerfasserIn] |
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| | Weinhold, Niels [VerfasserIn] |
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| | Maura, Francesco [VerfasserIn] |
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| Titel: | The biological and clinical impact of deletions before and after large chromosomal gains in multiple myeloma |
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| Verf.angabe: | Anthony M. Cirrincione, Alexandra M. Poos, Bachisio Ziccheddu, Marcella Kaddoura, Marc-Andrea Bärtsch, Kylee Maclachlan, Monika Chojnacka, Benjamin Diamond, Lukas John, Philipp Reichert, Stefanie Huhn, Patrick Blaney, Dylan Gagler, Karsten Rippe, Yanming Zhang, Ahmet Dogan, Alexander M. Lesokhin, Faith Davies, Hartmut Goldschmidt, Roland Fenk, Katja C. Weisel, Elias K. Mai, Neha Korde, Gareth J. Morgan, Saad Usmani, Ola Landgren, Marc S. Raab, Niels Weinhold, Francesco Maura |
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| E-Jahr: | 2024 |
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| Jahr: | August 15, 2024 |
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| Umfang: | 13 S. |
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| Fussnoten: | Gesehen am 06.11.2024 |
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| Titel Quelle: | Enthalten in: Blood |
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| Ort Quelle: | Washington, DC : American Society of Hematology, 1946 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 144(2024), 7 vom: Aug., Seite 771-783 |
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| ISSN Quelle: | 1528-0020 |
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| Abstract: | Acquisition of a hyperdiploid (HY) karyotype or immunoglobulin heavy chain (IgH) translocations are considered key initiating events in multiple myeloma (MM). To explore if other genomic events can precede these events, we analyzed whole-genome sequencing data from 1173 MM samples. By integrating molecular time and structural variants within early chromosomal duplications, we indeed identified pregain deletions in 9.4% of patients with an HY karyotype without IgH translocations, challenging acquisition of an HY karyotype as the earliest somatic event. Remarkably, these deletions affected tumor suppressor genes (TSGs) and/or oncogenes in 2.4% of patients with an HY karyotype without IgH translocations, supporting their role in MM pathogenesis. Furthermore, our study points to postgain deletions as novel driver mechanisms in MM. Using multiomics approaches to investigate their biologic impact, we found associations with poor clinical outcome in newly diagnosed patients and profound effects on both the oncogene and TSG activity despite the diploid gene status. Overall, this study provides novel insights into the temporal dynamics of genomic alterations in MM. |
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| DOI: | doi:10.1182/blood.2024024299 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1182/blood.2024024299 |
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| | DOI: https://doi.org/10.1182/blood.2024024299 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1907763589 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ biological and clinical impact of deletions before and after large chromosomal gains in multiple myeloma / Cirrincione, Anthony [VerfasserIn]; August 15, 2024 (Online-Ressource)
