| |  Online-Ressource |
|---|
| Verfasst von: | Tang, Kang [VerfasserIn]  |
|---|
| | Sun, Qianru [VerfasserIn] |
|---|
| | Zeng, Jinfeng [VerfasserIn] |
|---|
| | Tang, Jing [VerfasserIn] |
|---|
| | Cheng, Peiwen [VerfasserIn] |
|---|
| | Qiu, Zekai [VerfasserIn] |
|---|
| | Long, Haoyu [VerfasserIn] |
|---|
| | Chen, Yilin [VerfasserIn] |
|---|
| | Zhang, Chi [VerfasserIn] |
|---|
| | Wei, Jie [VerfasserIn] |
|---|
| | Qiu, Xiaoping [VerfasserIn] |
|---|
| | Jiang, Guozhi [VerfasserIn] |
|---|
| | Fang, Qianglin [VerfasserIn] |
|---|
| | Sun, Litao [VerfasserIn] |
|---|
| | Sun, Caijun [VerfasserIn] |
|---|
| | Du, Xiangjun [VerfasserIn] |
|---|
| Titel: | Network-based approach for drug repurposing against mpox |
|---|
| Verf.angabe: | Kang Tang, Qianru Sun, Jinfeng Zeng, Jing Tang, Peiwen Cheng, Zekai Qiu, Haoyu Long, Yilin Chen, Chi Zhang, Jie Wei, Xiaoping Qiu, Guozhi Jiang, Qianglin Fang, Litao Sun, Caijun Sun, Xiangjun Du |
|---|
| E-Jahr: | 2024 |
|---|
| Jahr: | 17 May 2024 |
|---|
| Umfang: | 10 S. |
|---|
| Illustrationen: | Illustrationen |
|---|
| Fussnoten: | Online verfügbar: 17 Mai 2024, Artikelversion: 18 Mai 2024 ; Gesehen am 11.11.2024 |
|---|
| Titel Quelle: | Enthalten in: International journal of biological macromolecules |
|---|
| Ort Quelle: | New York, NY [u.a.] : Elsevier, 1979 |
|---|
| Jahr Quelle: | 2024 |
|---|
| Band/Heft Quelle: | 270(2024), 2 vom: Juni, Artikel-ID 132468, Seite 1-10 |
|---|
| ISSN Quelle: | 1879-0003 |
|---|
| Abstract: | The current outbreak of mpox presents a significant threat to the global community. However, the lack of mpox-specific drugs necessitates the identification of additional candidates for clinical trials. In this study, a network medicine framework was used to investigate poxviruses-human interactions to identify potential drugs effective against the mpox virus (MPXV). The results indicated that poxviruses preferentially target hubs on the human interactome, and that these virally-targeted proteins (VTPs) tend to aggregate together within specific modules. Comorbidity analysis revealed that mpox is closely related to immune system diseases. Based on predicted drug-target interactions, 268 drugs were identified using the network proximity approach, among which 23 drugs displaying the least side-effects and significant proximity to MPXV were selected as the final candidates. Lastly, specific drugs were explored based on VTPs, differentially expressed proteins, and intermediate nodes, corresponding to different categories. These findings provide novel insights that can contribute to a deeper understanding of the pathogenesis of MPXV and development of ready-to-use treatment strategies based on drug repurposing. |
|---|
| DOI: | doi:10.1016/j.ijbiomac.2024.132468 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.ijbiomac.2024.132468 |
|---|
| | Volltext: https://www.sciencedirect.com/science/article/pii/S0141813024032732 |
|---|
| | DOI: https://doi.org/10.1016/j.ijbiomac.2024.132468 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Comorbidity |
|---|
| | Drug repurposing |
|---|
| | Mpox |
|---|
| | Virushost interaction |
|---|
| K10plus-PPN: | 1908141220 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Network-based approach for drug repurposing against mpox / Tang, Kang [VerfasserIn]; 17 May 2024 (Online-Ressource)
