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Status: Bibliographieeintrag

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Verfasst von:Zhong, Changhao [VerfasserIn]   i
 Chen, Enguo [VerfasserIn]   i
 Su, Zhuquan [VerfasserIn]   i
 Chen, Difei [VerfasserIn]   i
 Wang, Feng [VerfasserIn]   i
 Wang, Xiaoping [VerfasserIn]   i
 Liu, Guangnan [VerfasserIn]   i
 Zhang, Xiaoju [VerfasserIn]   i
 Luo, Fengming [VerfasserIn]   i
 Zhang, Nan [VerfasserIn]   i
 Wang, Hongwu [VerfasserIn]   i
 Jin, Longyu [VerfasserIn]   i
 Long, Fa [VerfasserIn]   i
 Liu, Chunfang [VerfasserIn]   i
 Wu, Shiman [VerfasserIn]   i
 Geng, Qing [VerfasserIn]   i
 Wang, Xiang [VerfasserIn]   i
 Tang, Chunli [VerfasserIn]   i
 Chen, Ruchong [VerfasserIn]   i
 Herth, Felix [VerfasserIn]   i
 Sun, Jiayuan [VerfasserIn]   i
 Li, Shiyue [VerfasserIn]   i
Titel:Safety and efficacy of a novel transbronchial radiofrequency ablation system for lung tumours
Titelzusatz:one year follow-up from the first multi-centre large-scale clinical trial (BRONC-RFII)
Verf.angabe:Changhao Zhong, Enguo Chen, Zhuquan Su, Difei Chen, Feng Wang, Xiaoping Wang, Guangnan Liu, Xiaoju Zhang, Fengming Luo, Nan Zhang, Hongwu Wang, Longyu Jin, Fa Long, Chunfang Liu, Shiman Wu, Qing Geng, Xiang Wang, Chunli Tang, Ruchong Chen, Felix J. F. Herth, Jiayuan Sun, Shiyue Li
E-Jahr:2024
Jahr:28 August 2024
Umfang:11 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 11.11.2024
Titel Quelle:Enthalten in: Respirology
Ort Quelle:Oxford [u.a.] : Wiley-Blackwell, 1996
Jahr Quelle:2024
Band/Heft Quelle:(2024), Seite 1-11
ISSN Quelle:1440-1843
Abstract:Background and Objective Radiofrequency ablation (RFA) is an emerging treatment of lung cancer, yet it is accompanied by certain safety concerns and operational limitations. This first multi-centre, large-scale clinical trial aimed to investigate the technical performance, efficacy and safety of an innovative transbronchial RFA system for lung tumours. Methods The study enrolled patients with malignant lung tumours who underwent transbronchial RFA using an automatic saline microperfusion system between January 2021 and December 2021 across 16 medical centres. The primary endpoint was the complete ablation rate. The performance and safety of the technique, along with the 1-year survival rates, were evaluated. Results This study included 126 patients (age range: 23-85 years) with 130 lung tumours (mean size: 18.77 × 14.15 mm) who had undergone 153 transbronchial RFA sessions, with a technique success rate of 99.35% and an average ablation zone size of 32.47 mm. At the 12-month follow-up, the complete ablation rate and intrapulmonary progression-free survival rates were 90.48% and 88.89%, respectively. The results of patients with ground-glass nodules (GGNs) were superior to those of the patients with solid nodules (12-month complete ablation rates: solid vs. pure GGN vs. mixed GGN: 82.14% vs. 100% vs. 96.08%, p = 0.007). No device defects were reported. Complications such as pneumothorax, haemoptysis, pleural effusion, pulmonary infection and pleural pain were observed in 3.97%, 6.35%, 8.73%, 11.11% and 10.32% of patients, respectively. Two subjects died during the follow-up period. Conclusion Transbronchial RFA utilizing an automatic saline microperfusion system is a viable, safe and efficacious approach for the treatment for lung tumours, particularly for patients with GGNs.
DOI:doi:10.1111/resp.14822
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1111/resp.14822
 kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/resp.14822
 DOI: https://doi.org/10.1111/resp.14822
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:bronchoscopy
 ground-glass nodule
 lung tumour
 radiofrequency ablation
K10plus-PPN:1908161450
Verknüpfungen:→ Zeitschrift

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