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| Verfasst von: | Abba, Mohammed L. [VerfasserIn]  |
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| | Riabov, Vladimir [VerfasserIn] |
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| | Nowak, Daniel [VerfasserIn] |
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| | Hofmann, Wolf-Karsten [VerfasserIn] |
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| | Boch, Tobias [VerfasserIn] |
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| Titel: | Understanding iron homeostasis in MDS |
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| Titelzusatz: | the role of erythroferrone |
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| Verf.angabe: | Mohammed L. Abba, Vladimir Riabov, Daniel Nowak, Wolf-Karsten Hofmann and Tobias Boch |
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| E-Jahr: | 2024 |
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| Jahr: | 21 May 2024 |
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| Umfang: | 6 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 11.11.2024 |
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| Titel Quelle: | Enthalten in: Frontiers in oncology |
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| Ort Quelle: | Lausanne : Frontiers Media, 2011 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 14(2024) vom: 21. Mai, Artikel-ID 1404817, Seite 1-6 |
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| ISSN Quelle: | 2234-943X |
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| Abstract: | Myelodysplastic neoplasms (MDS) are a heterogenous group of clonal stem cell disorders characterized by dysplasia and cytopenia in one or more cell lineages. Anemia is a very common symptom that is often treated with blood transfusions and/or erythropoiesis stimulating factors. Iron overload results from a combination of these factors together with the disease-associated ineffective erythropoiesis, that is seen especially in MDS cases with SF3B1 mutations. A growing body of research has shown that erythroferrone is an important regulator of hepcidin, the master regulator of systemic iron homeostasis. Consequently, it is of interest to understand how this molecule contributes to regulating the iron balance in MDS patients. This short review evaluates our current understanding of erythroferrone in general, but more specifically in MDS and seeks to place in context how the current knowledge could be utilized for prognostication and therapy. |
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| DOI: | doi:10.3389/fonc.2024.1404817 |
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| URL: | kostenfrei: Volltext: https://doi.org/10.3389/fonc.2024.1404817 |
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| | kostenfrei: Volltext: https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1404817/full |
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| | DOI: https://doi.org/10.3389/fonc.2024.1404817 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Erythroferrone |
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| | hepcidin |
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| | Iron Overload |
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| | Myelodysplastic neoplasms |
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| | SF3B1 mutations |
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| K10plus-PPN: | 1908230967 |
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| Verknüpfungen: | → Zeitschrift |
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| Lokale URL UB: |  Zum Volltext |
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Understanding iron homeostasis in MDS / Abba, Mohammed L. [VerfasserIn]; 21 May 2024 (Online-Ressource)
69272387
