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| Verfasst von: | Peruchet-Noray, Laia [VerfasserIn]  |
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| | Sedlmeier, Anja M. [VerfasserIn] |
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| | Dimou, Niki [VerfasserIn] |
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| | Baurecht, Hansjörg [VerfasserIn] |
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| | Fervers, Béatrice [VerfasserIn] |
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| | Fontvieille, Emma [VerfasserIn] |
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| | Konzok, Julian [VerfasserIn] |
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| | Tsilidis, Kostas K. [VerfasserIn] |
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| | Christakoudi, Sofia [VerfasserIn] |
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| | Jansana, Anna [VerfasserIn] |
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| | Cordova, Reynalda [VerfasserIn] |
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| | Bohmann, Patricia [VerfasserIn] |
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| | Stein, Michael J. [VerfasserIn] |
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| | Weber, Andrea [VerfasserIn] |
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| | Bézieau, Stéphane [VerfasserIn] |
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| | Brenner, Hermann [VerfasserIn] |
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| | Chan, Andrew T. [VerfasserIn] |
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| | Cheng, Iona [VerfasserIn] |
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| | Figueiredo, Jane C. [VerfasserIn] |
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| | Garcia-Etxebarria, Koldo [VerfasserIn] |
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| | Moreno, Victor [VerfasserIn] |
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| | Newton, Christina C. [VerfasserIn] |
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| | Schmit, Stephanie L. [VerfasserIn] |
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| | Song, Mingyang [VerfasserIn] |
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| | Ulrich, Cornelia [VerfasserIn] |
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| | Ferrari, Pietro [VerfasserIn] |
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| | Viallon, Vivian [VerfasserIn] |
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| | Carreras-Torres, Robert [VerfasserIn] |
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| | Gunter, Marc J. [VerfasserIn] |
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| | Freisling, Heinz [VerfasserIn] |
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| Titel: | Tissue-specific genetic variation suggests distinct molecular pathways between body shape phenotypes and colorectal cancer |
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| Verf.angabe: | Laia Peruchet-Noray, Anja M. Sedlmeier, Niki Dimou, Hansjörg Baurecht, Béatrice Fervers, Emma Fontvieille, Julian Konzok, Kostas K. Tsilidis, Sofia Christakoudi, Anna Jansana, Reynalda Cordova, Patricia Bohmann, Michael J. Stein, Andrea Weber, Stéphane Bézieau, Hermann Brenner, Andrew T. Chan, Iona Cheng, Jane C. Figueiredo, Koldo Garcia-Etxebarria, Victor Moreno, Christina C. Newton, Stephanie L. Schmit, Mingyang Song, Cornelia M. Ulrich, Pietro Ferrari, Vivian Viallon, Robert Carreras-Torres, Marc J. Gunter, Heinz Freisling |
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| E-Jahr: | 2024 |
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| Jahr: | Apr 2024 |
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| Umfang: | 15 S. |
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| Illustrationen: | Illustrationen, Diagramme |
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| Fussnoten: | Online veröffentlicht: 19. April 2024 ; Gesehen am 12.11.2024 |
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| Titel Quelle: | Enthalten in: Science advances |
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| Ort Quelle: | Washington, DC [u.a.] : Assoc., 2015 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 10(2024), 16 vom: Apr., Artikel-ID eadj1987, Seite 1-15 |
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| ISSN Quelle: | 2375-2548 |
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| Abstract: | It remains unknown whether adiposity subtypes are differentially associated with colorectal cancer (CRC). To move beyond single-trait anthropometric indicators, we derived four multi-trait body shape phenotypes reflecting adiposity subtypes from principal components analysis on body mass index, height, weight, waist-to-hip ratio, and waist and hip circumference. A generally obese (PC1) and a tall, centrally obese (PC3) body shape were both positively associated with CRC risk in observational analyses in 329,828 UK Biobank participants (3728 cases). In genome-wide association studies in 460,198 UK Biobank participants, we identified 3414 genetic variants across four body shapes and Mendelian randomization analyses confirmed positive associations of PC1 and PC3 with CRC risk (52,775 cases/45,940 controls from GECCO/CORECT/CCFR). Brain tissue-specific genetic instruments, mapped to PC1 through enrichment analysis, were responsible for the relationship between PC1 and CRC, while the relationship between PC3 and CRC was predominantly driven by adipose tissue-specific genetic instruments. This study suggests distinct putative causal pathways between adiposity subtypes and CRC. |
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| DOI: | doi:10.1126/sciadv.adj1987 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1126/sciadv.adj1987 |
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| | kostenfrei: Volltext: https://www.science.org/doi/10.1126/sciadv.adj1987 |
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| | DOI: https://doi.org/10.1126/sciadv.adj1987 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1908325011 |
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| Verknüpfungen: | → Zeitschrift |
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Tissue-specific genetic variation suggests distinct molecular pathways between body shape phenotypes and colorectal cancer / Peruchet-Noray, Laia [VerfasserIn]; Apr 2024 (Online-Ressource)
