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Verfasst von:Zhang, Ke [VerfasserIn]   i
 Triphan, Simon M. F. [VerfasserIn]   i
 Wielpütz, Mark Oliver [VerfasserIn]   i
 Ziener, Christian H. [VerfasserIn]   i
 Ladd, Mark E. [VerfasserIn]   i
 Schlemmer, Heinz-Peter [VerfasserIn]   i
 Kauczor, Hans-Ulrich [VerfasserIn]   i
 Sedlaczek, Oliver [VerfasserIn]   i
 Kurz, Felix T. [VerfasserIn]   i
Titel:Navigator-based motion compensation for liver BOLD measurement with five-echo SAGE EPI and breath-hold task
Verf.angabe:Ke Zhang, Simon M.F. Triphan, Mark O. Wielpütz, Christian H. Ziener, Mark E. Ladd, Heinz-Peter Schlemmer, Hans-Ulrich Kauczor, Oliver Sedlaczek, Felix T. Kurz
E-Jahr:2024
Jahr:October 2024
Umfang:11 S.
Illustrationen:Illustrationen
Fussnoten:Erstveröffentlichung: 24 May 2024 ; Gesehen am 13.11.2024
Titel Quelle:Enthalten in: NMR in biomedicine
Ort Quelle:New York, NY : Wiley, 1988
Jahr Quelle:2024
Band/Heft Quelle:37(2024), 10 vom: Okt., Artikel-ID e5173, Seite 1-11
ISSN Quelle:1099-1492
Abstract:Purpose The purpose of this work is to apply multi-echo spin- and gradient-echo (SAGE) echo-planar imaging (EPI) combined with a navigator-based (NAV) prospective motion compensation method for a quantitative liver blood oxygen level dependent (BOLD) measurement with a breath-hold (BH) task. Methods A five-echo SAGE sequence was developed to quantitatively measure T2 and T2* to depict function with sufficient signal-to-noise ratio, spatial resolution and sensitivity to BOLD changes induced by the BH task. To account for respiratory motion, a navigator was employed in the form of a single gradient-echo projection readout, located at the diaphragm along the inferior-superior direction. Prior to each transverse imaging slice of the spin-echo EPI-based readouts, navigator acquisition and fat suppression were incorporated. Motion data was obtained from the navigator and transmitted back to the sequence, allowing real-time adjustments to slice positioning. Six healthy volunteers and three patients with liver carcinoma were included in this study. Quantitative T2 and T2* were calculated at each time point of the BH task. Parameters of t value from first-level analysis using a general linear model and hepatovascular reactivity (HVR) of Echo1, T2 and T2* were calculated. Results The motion caused by respiratory activity was successfully compensated using the navigator signal. The average changes of T2 and T2* during breath-hold were about 1% and 0.7%, respectively. With the help of NAV prospective motion compensation whole liver t values could be obtained without motion artifacts. The quantified liver T2 (34.7 ± 0.7 ms) and T2* (29 ± 1.2 ms) values agreed with values from literature. In healthy volunteers, the distribution of statistical t value and HVR was homogeneous throughout the whole liver. In patients with liver carcinoma, the distribution of t value and HVR was inhomogeneous due to metastases or therapy. Conclusions This study demonstrates the feasibility of using a NAV prospective motion compensation technique in conjunction with five-echo SAGE EPI for the quantitative measurement of liver BOLD with a BH task.
DOI:doi:10.1002/nbm.5173
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1002/nbm.5173
 kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/nbm.5173
 DOI: https://doi.org/10.1002/nbm.5173
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:hepatovascular reactivity
 navigator-based slice tracking
 prospective motion compensation
 quantitative liver BOLD
K10plus-PPN:1908406585
Verknüpfungen:→ Zeitschrift

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