| |  Online-Ressource |
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| Verfasst von: | Vinsensia, Maria [VerfasserIn]  |
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| | Schaub, Riccarda [VerfasserIn] |
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| | Meixner, Eva [VerfasserIn] |
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| | Hoegen-Saßmannshausen, Philipp [VerfasserIn] |
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| | Arians, Nathalie [VerfasserIn] |
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| | Forster, Tobias [VerfasserIn] |
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| | Hoeltgen, Line [VerfasserIn] |
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| | Köhler, Clara [VerfasserIn] |
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| | Uzun-Lang, Kristin [VerfasserIn] |
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| | Batista, Vania [VerfasserIn] |
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| | König, Laila [VerfasserIn] |
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| | Zivanovic, Oliver [VerfasserIn] |
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| | Hennigs, André [VerfasserIn] |
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| | Golatta, Michael [VerfasserIn] |
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| | Heil, Jörg [VerfasserIn] |
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| | Debus, Jürgen [VerfasserIn] |
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| | Hörner-Rieber, Juliane [VerfasserIn] |
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| Titel: | Incidence and risk assessment of capsular contracture in breast cancer patients following post-mastectomy radiotherapy and implant-based reconstruction |
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| Verf.angabe: | Maria Vinsensia, Riccarda Schaub, Eva Meixner, Philipp Hoegen, Nathalie Arians, Tobias Forster, Line Hoeltgen, Clara Köhler, Kristin Uzun-Lang, Vania Batista, Laila König, Oliver Zivanovic, Andre Hennigs, Michael Golatta, Jörg Heil, Jürgen Debus, Juliane Hörner-Rieber |
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| E-Jahr: | 2024 |
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| Jahr: | 7 January 2024 |
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| Umfang: | 15 S. |
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| Fussnoten: | Gesehen am 14.11.2024 |
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| Titel Quelle: | Enthalten in: Cancers |
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| Ort Quelle: | Basel : MDPI, 2009 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 16(2024), 2, Artikel-ID 265, Seite 1-15 |
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| ISSN Quelle: | 2072-6694 |
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| Abstract: | Our study aims to identify the risk factors and dosimetry characteristics associated with capsular contracture. Methods: We retrospectively analyzed 118 women with breast cancer who underwent PMRT following an IBR between 2010 and 2022. Patients were treated with PMRT of 50.0-50.4 Gy in 25-28 fractions. Capsular contracture was categorized according to the Baker Classification for Reconstructed Breasts. Results: After a median follow-up of 22 months, the incidence of clinically relevant capsular contracture (Baker III-IV) was 22.9%. Overall, capsular contracture (Baker I-IV) occurred in 56 patients (47.5%) after a median of 9 months after PMRT. The rate of reconstruction failure/implant loss was 25.4%. In the univariate analysis, postoperative complications (prolonged pain, prolonged wound healing, seroma and swelling) and regional nodal involvement were associated with higher rates of capsular contracture (p = 0.017, OR: 2.5, 95% CI: 1.2-5.3 and p = 0.031, respectively). None of the analyzed dosimetric factors or the implant position were associated with a higher risk for capsular contracture. Conclusion: Postoperative complications and regional nodal involvement were associated with an increased risk of capsular contracture following breast reconstruction and PMRT, while none of the analyzed dosimetric factors were linked to a higher incidence. Additional studies are needed to identify further potential risk factors. |
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| DOI: | doi:10.3390/cancers16020265 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/cancers16020265 |
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| | kostenfrei: Volltext: https://www.mdpi.com/2072-6694/16/2/265 |
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| | DOI: https://doi.org/10.3390/cancers16020265 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | breast cancer |
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| | breast reconstruction |
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| | capsular contracture |
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| | capsular fibrosis |
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| | immediate implant-based breast reconstruction |
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| | post-mastectomy radiotherapy |
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| K10plus-PPN: | 1908720239 |
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| Verknüpfungen: | → Zeitschrift |
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Incidence and risk assessment of capsular contracture in breast cancer patients following post-mastectomy radiotherapy and implant-based reconstruction / Vinsensia, Maria [VerfasserIn]; 7 January 2024 (Online-Ressource)
