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| Verfasst von: | Tucker, Sarah A. [VerfasserIn]  |
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| | Hu, Song-Hua [VerfasserIn] |
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| | Vyas, Sejal [VerfasserIn] |
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| | Park, Albert [VerfasserIn] |
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| | Joshi, Shakchhi [VerfasserIn] |
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| | Inal, Aslihan [VerfasserIn] |
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| | Lam, Tiffany [VerfasserIn] |
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| | Tan, Emily [VerfasserIn] |
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| | Haigis, Kevin M. [VerfasserIn] |
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| | Haigis, Marcia C. [VerfasserIn] |
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| Titel: | SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis |
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| Verf.angabe: | Sarah A. Tucker, Song-Hua Hu, Sejal Vyas, Albert Park, Shakchhi Joshi, Aslihan Inal, Tiffany Lam, Emily Tan, Kevin M. Haigis, Marcia C. Haigis |
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| E-Jahr: | 2024 |
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| Jahr: | April 23, 2024 |
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| Umfang: | 22 S. |
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| Fussnoten: | Gesehen am 14.11.2024 |
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| Titel Quelle: | Enthalten in: Cell reports |
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| Ort Quelle: | Maryland Heights, MO : Cell Press, 2012 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 43(2024), 4, Artikel-ID 113975, Seite 113975-1-113975-22 |
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| ISSN Quelle: | 2211-1247 |
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| Abstract: | The intestine is a highly metabolic tissue, but the metabolic programs that influence intestinal crypt proliferation, differentiation, and regeneration are still emerging. Here, we investigate how mitochondrial sirtuin 4 (SIRT4) affects intestinal homeostasis. Intestinal SIRT4 loss promotes cell proliferation in the intestine following ionizing radiation (IR). SIRT4 functions as a tumor suppressor in a mouse model of intestinal cancer, and SIRT4 loss drives dysregulated glutamine and nucleotide metabolism in intestinal adenomas. Intestinal organoids lacking SIRT4 display increased proliferation after IR stress, along with increased glutamine uptake and a shift toward de novo nucleotide biosynthesis over salvage pathways. Inhibition of de novo nucleotide biosynthesis diminishes the growth advantage of SIRT4-deficient organoids after IR stress. This work establishes SIRT4 as a modulator of intestinal metabolism and homeostasis in the setting of DNA-damaging stress. |
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| DOI: | doi:10.1016/j.celrep.2024.113975 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.celrep.2024.113975 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S2211124724003036 |
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| | DOI: https://doi.org/10.1016/j.celrep.2024.113975 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | glutamine |
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| | intestinal organoids |
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| | irradiation |
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| | nucleotide biosynthesis |
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| | nucleotide metabolism |
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| | SIRT4 |
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| | sirtuin |
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| K10plus-PPN: | 190872482X |
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| Verknüpfungen: | → Zeitschrift |
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SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis / Tucker, Sarah A. [VerfasserIn]; April 23, 2024 (Online-Ressource)
