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| Verfasst von: | Urban, Katharina [VerfasserIn]  |
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| | Gkeka, Anastasia [VerfasserIn] |
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| | Chandra, Monica [VerfasserIn] |
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| | Greiner, Dennis [VerfasserIn] |
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| | Pollich, Selina [VerfasserIn] |
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| | Ruf, Sandra [VerfasserIn] |
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| | Kelemen, Yosip [VerfasserIn] |
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| | Sundermann, Tom R. [VerfasserIn] |
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| | Pravetoni, Marco [VerfasserIn] |
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| | Baehr, Carly [VerfasserIn] |
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| | Stebbins, Erec [VerfasserIn] |
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| | Papavasiliou, Nina [VerfasserIn] |
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| | Verdi, Joseph P. [VerfasserIn] |
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| Titel: | The fentanyl-specific antibody FenAb024 can shield against carfentanil effects |
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| Verf.angabe: | Katharina Urban, Anastasia Gkeka, Monica Chandra, Dennis Greiner, Selina Pollich, Sandra Ruf, Yosip Kelemen, Tom Sundermann, Marco Pravetoni, Carly Baehr, C. Erec Stebbins, F. Nina Papavasiliou, Joseph P. Verdi |
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| E-Jahr: | 2024 |
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| Jahr: | 15 May 202 |
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| Umfang: | 10 S. |
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| Illustrationen: | Illustrationen, Diagramme |
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| Fussnoten: | Online verfügbar 6 April 2024, Version des Artikels 13 April 2024 ; Gesehen am 15.11.2024 |
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| Titel Quelle: | Enthalten in: Toxicology letters |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1977 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 396(2024) vom: Mai, Seite 1-10 |
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| ISSN Quelle: | 1879-3169 |
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| Abstract: | The surge in opioid-related deaths, driven predominantly by fentanyl and its synthetic derivatives, has become a critical public health concern, which is particularly evident in the United States. While the situation is less severe in Europe, the European Monitoring Centre for Drugs and Drug Addiction reports a rise in drug overdose deaths, with emerging concerns about the impact of fentanyl-related molecules. Synthetic opioids, initially designed for medical use, have infiltrated illicit markets due to their low production costs and high potency, with carfentanil posing additional threats, including potential chemical weaponization. Existing overdose mitigation heavily relies on naloxone, requiring timely intervention and caregiver presence, while therapeutic prevention strategies face many access challenges. To provide an additional treatment option, we propose the use of a fentanyl-specific monoclonal antibody (mAb), as a non-opioid method of prophylaxis against fentanyl and carfentanil. This mAb shows protection from opioid effects in a pre-clinical murine model. mAbs could emerge as a versatile countermeasure in civilian and biodefense settings, offering a novel approach to combat opioid-associated mortality. |
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| DOI: | doi:10.1016/j.toxlet.2024.03.008 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1016/j.toxlet.2024.03.008 |
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| | kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S0378427424000559 |
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| | DOI: https://doi.org/10.1016/j.toxlet.2024.03.008 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Antibody-associated protection |
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| | Carfentanil |
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| | Fentanyl |
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| | Monoclonal antibodies |
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| | Opioid crisis |
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| | Passive immunization |
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| K10plus-PPN: | 1908744073 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ fentanyl-specific antibody FenAb024 can shield against carfentanil effects / Urban, Katharina [VerfasserIn]; 15 May 202 (Online-Ressource)
