Task-induced deactivation dysfunction during reward processing is associated with low self-esteem in a possible subtype of major depression

• Verfasst von: Jüllig, Antonia [VerfasserIn]
• Verfasst von: Hebib, Sandi [VerfasserIn]
• Verfasst von: Metzker, Helena [VerfasserIn]
• Verfasst von: Gruber, Eva Stefanie [VerfasserIn]
• Verfasst von: Gruber, Oliver [VerfasserIn]
• Titel: Task-induced deactivation dysfunction during reward processing is associated with low self-esteem in a possible subtype of major depression
• Verf.angabe: Antonia K. Jüllig, Sandi Hebib, Helena Metzker, Eva Gruber, Oliver Gruber
• E-Jahr: 2024
• Jahr: June 2024
• Umfang: 11 S.
• Illustrationen: Illustrationen
• Fussnoten: Zuerst veröffentlicht: 14. Juni 2024 ; Gesehen am 15.11.2024
• Titel Quelle: Enthalten in: Brain and behavior
• Ort Quelle: Malden, Mass. : Wiley, 2011
• Jahr Quelle: 2024
• Band/Heft Quelle: 14(2024), 6 vom: Juni, Artikel-ID e3545, Seite 1-11
• ISSN Quelle: 2162-3279
• DOI: doi:10.1002/brb3.3545
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: major depressive disorder
• Sach-SW: pregenual anterior cingulate
• Sach-SW: reward
• Sach-SW: self-esteem
• Sach-SW: subtype
• Sach-SW: task-induced deactivation
• K10plus-PPN: 1908755792

Abstract

Introduction Low self-esteem is a frequent symptom in major depressive disorder (MDD). This functional magnetic resonance imaging study investigated whether MDD patients with low self-esteem show a distinct neural pathophysiology. Previous studies linked low self-esteem to reduced task-induced deactivation of the pregenual anterior cingulate cortex (pgACC) as a part of the default mode network, and to reduced connectivity between pgACC and reward system. Goya-Maldonado et al. identified an MDD subtype with pgACC and ventral striatal overactivations during reward processing. We hypothesized that this subtype might be characterized by low self-esteem. Methods Eighty-three MDD patients performed the desire-reason dilemma task and completed the Rosenberg Self-Esteem Scale (RSES). Brain activity during bottom-up reward processing was regressed upon the RSES scores, controlling for depression severity measured by the Montgomery-Åsberg Depression Rating Scale. To corroborate the findings, we compared self-esteem scores between patient subgroups with impaired task-induced deactivation (n = 31) and with preserved task-induced deactivation (n = 31) of the pgACC. Results Consistent with our a priori hypothesis, activity in a bilateral fronto-striatal network including pgACC and ventral striatum correlated negatively with RSES scores, also when controlling for depression severity. In the additional analysis, patients with impaired task-induced pgACC deactivation showed lower self-esteem (t (52.82) = −2.27; p = .027, d = 0.58) compared to those with preserved task-induced pgACC deactivation. Conclusions We conclude that low self-esteem in MDD patients is linked to a task-induced deactivation dysfunction of the pgACC. Our findings suggest that a previously described possible subtype of MDD with pgACC and ventral striatal overactivations during reward processing is clinically characterized by low self-esteem.