Status: Bibliographieeintrag
Standort: ---
Exemplare:
---
| |  Online-Ressource |
|---|
| Verfasst von: | Thiel, Daniel [VerfasserIn]  |
|---|
| | Yañez Guerra, Luis Alfonso [VerfasserIn] |
|---|
| | Kieswetter, Amanda [VerfasserIn] |
|---|
| | Cole, Alison G [VerfasserIn] |
|---|
| | Temmerman, Liesbet [VerfasserIn] |
|---|
| | Technau, Ulrich [VerfasserIn] |
|---|
| | Jékely, Gáspár [VerfasserIn] |
|---|
| Titel: | Large-scale deorphanization of Nematostella vectensis neuropeptide G protein-coupled receptors supports the independent expansion of bilaterian and cnidarian peptidergic systems |
|---|
| Verf.angabe: | Daniel Thiel, Luis Alfonso Yañez Guerra, Amanda Kieswetter, Alison G Cole, Liesbet Temmerman, Ulrich Technau, Gáspár Jékely |
|---|
| E-Jahr: | 2024 |
|---|
| Jahr: | 10 May 2024 |
|---|
| Umfang: | 27 S. |
|---|
| Fussnoten: | Gesehen am 15.11.2024 |
|---|
| Titel Quelle: | Enthalten in: eLife |
|---|
| Ort Quelle: | Cambridge : eLife Sciences Publications, 2012 |
|---|
| Jahr Quelle: | 2024 |
|---|
| Band/Heft Quelle: | 12(2024), Artikel-ID RP90674, Seite RP90674-1-RP90674-27 |
|---|
| ISSN Quelle: | 2050-084X |
|---|
| Abstract: | Neuropeptides are ancient signaling molecules in animals but only few peptide receptors are known outside bilaterians. Cnidarians possess a large number of G protein-coupled receptors (GPCRs) - the most common receptors of bilaterian neuropeptides - but most of these remain orphan with no known ligands. We searched for neuropeptides in the sea anemone Nematostella vectensis and created a library of 64 peptides derived from 33 precursors. In a large-scale pharmacological screen with these peptides and 161 N. vectensis GPCRs, we identified 31 receptors specifically activated by 1 to 3 of 14 peptides. Mapping GPCR and neuropeptide expression to single-cell sequencing data revealed how cnidarian tissues are extensively connected by multilayer peptidergic networks. Phylogenetic analysis identified no direct orthology to bilaterian peptidergic systems and supports the independent expansion of neuropeptide signaling in cnidarians from a few ancestral peptide-receptor pairs. |
|---|
| DOI: | doi:10.7554/eLife.90674 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.7554/eLife.90674 |
|---|
| | DOI: https://doi.org/10.7554/eLife.90674 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Clytia hemisphaerica |
|---|
| | Exaiptasia pallida |
|---|
| | GPCR |
|---|
| | Hydra vulgaris |
|---|
| | Nematostella vectensis |
|---|
| | neuropeptide |
|---|
| K10plus-PPN: | 1908762217 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Large-scale deorphanization of Nematostella vectensis neuropeptide G protein-coupled receptors supports the independent expansion of bilaterian and cnidarian peptidergic systems / Thiel, Daniel [VerfasserIn]; 10 May 2024 (Online-Ressource)
69273912
