Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Holthuijsen, Daniëlle [VerfasserIn]   i
 van Roekel, Eline H. [VerfasserIn]   i
 Bours, Martijn J. L. [VerfasserIn]   i
 Ueland, Per M. [VerfasserIn]   i
 Breukink, Stéphanie O. [VerfasserIn]   i
 Janssen-Heijnen, Maryska L. G. [VerfasserIn]   i
 Keulen, Eric T. P. [VerfasserIn]   i
 Brezina, Stefanie [VerfasserIn]   i
 Gigić, Biljana [VerfasserIn]   i
 Peoples, Anita R. [VerfasserIn]   i
 Ulrich, Cornelia [VerfasserIn]   i
 Ulvik, Arve [VerfasserIn]   i
 Weijenberg, Matty P. [VerfasserIn]   i
 Eussen, Simone J. P. M. [VerfasserIn]   i
Titel:Longitudinal associations of plasma kynurenines and ratios with fatigue and quality of life in colorectal cancer survivors up to 12 months post-treatment
Verf.angabe:Daniëlle D.B. Holthuijsen, Eline H. van Roekel, Martijn J.L. Bours, Per M. Ueland, Stéphanie O. Breukink, Maryska L.G. Janssen-Heijnen, Eric T.P. Keulen, Stefanie Brezina, Biljana Gigic, Anita R. Peoples, Cornelia M. Ulrich, Arve Ulvik, Matty P. Weijenberg, Simone J.P.M. Eussen
E-Jahr:2024
Jahr:1 October 2024
Umfang:19 S.
Fussnoten:Gesehen am 18.11.2024 ; Veröffentlicht: 23 May 2024
Titel Quelle:Enthalten in: International journal of cancer
Ort Quelle:Bognor Regis : Wiley-Liss, 1966
Jahr Quelle:2024
Band/Heft Quelle:155(2024), 7 vom: Okt., Seite 1172-1190
ISSN Quelle:1097-0215
Abstract:Fatigue is prevalent in colorectal cancer (CRC) survivors, impacting their health-related quality of life (HRQoL). Inflammation-induced activation of the kynurenine pathway may play a role in cancer-related fatigue and HRQoL, but evidence is scarce. Therefore, we aimed to investigate longitudinal associations of plasma tryptophan, kynurenines, and ratios with fatigue and HRQoL in CRC survivors up to 12 months post-treatment. Repeated measurements at 6 weeks, 6 months, and 12 months post-treatment were performed in 249 stage I-III CRC survivors. Plasma tryptophan and eight kynurenines were analyzed using liquid chromatography-tandem mass spectrometry (LC/MS-MS). Fatigue and HRQoL outcomes were evaluated using validated questionnaires. Confounder-adjusted linear mixed models were conducted to analyze longitudinal associations, with false discovery rate (FDR) correction. Higher tryptophan (Trp), kynurenic acid (KA), and xanthurenic acid (XA) concentrations, as well as a higher kynurenic acid-to-quinolinic acid ratio (KA/QA), were associated with less fatigue and better functioning, while a higher kynurenine-to-tryptophan ratio (KTR) and 3-hydroxykynurenine ratio (HKr) were associated with more fatigue and worse functioning. Finally, higher KA and XA concentrations and a higher KA/QA ratio were associated with a higher overall HRQoL summary score, while a higher HKr was associated with a lower overall HRQoL summary score. In conclusion, we observed that tryptophan and several kynurenines were longitudinally associated with fatigue and HRQoL in CRC survivors up to 12 months post-treatment. Future research is needed to validate our findings and explore the potential of the kynurenine pathway as intervention target for reducing fatigue and enhancing HRQoL after CRC treatment.
DOI:doi:10.1002/ijc.34992
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1002/ijc.34992
 kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.34992
 DOI: https://doi.org/10.1002/ijc.34992
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:colorectal cancer survivorship
 fatigue
 health-related quality of life
 plasma kynurenines
 tryptophan
K10plus-PPN:1908847123
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/69274428   QR-Code
zum Seitenanfang