A systems view of the vascular endothelium in health and disease

• Verfasst von: Augustin, Hellmut [VerfasserIn]
• Verfasst von: Koh, Gou Young [VerfasserIn]
• Titel: A systems view of the vascular endothelium in health and disease
• Verf.angabe: Hellmut G. Augustin, Gou Young Koh
• E-Jahr: 2024
• Jahr: 5 September 2024
• Umfang: 26 S.
• Illustrationen: Illustrationen
• Fussnoten: Online verfügbar: 5. September 2024, Artikelversion: 5. September 2024 ; Gesehen am 18.11.2024
• Titel Quelle: Enthalten in: Cell
• Ort Quelle: [Cambridge, Mass.] : Cell Press, 1974
• Jahr Quelle: 2024
• Band/Heft Quelle: 187(2024), 18, Seite 4833-4858
• ISSN Quelle: 1097-4172
• DOI: doi:10.1016/j.cell.2024.07.012
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1908883707

Abstract

The dysfunction of blood-vessel-lining endothelial cells is a major cause of mortality. Although endothelial cells, being present in all organs as a single-cell layer, are often conceived as a rather inert cell population, the vascular endothelium as a whole should be considered a highly dynamic and interactive systemically disseminated organ. We present here a holistic view of the field of vascular research and review the diverse functions of blood-vessel-lining endothelial cells during the life cycle of the vasculature, namely responsive and relaying functions of the vascular endothelium and the responsive roles as instructive gatekeepers of organ function. Emerging translational perspectives in regenerative medicine, preventive medicine, and aging research are developed. Collectively, this review is aimed at promoting disciplinary coherence in the field of angioscience for a broader appreciation of the importance of the vasculature for organ function, systemic health, and healthy aging.