Immunological aspects of necrotizing enterocolitis models

• Verfasst von: Blum, Laura [VerfasserIn]
• Verfasst von: Vincent, Deirdre [VerfasserIn]
• Verfasst von: Boettcher, Michael [VerfasserIn]
• Verfasst von: Knopf, Jasmin [VerfasserIn]
• Titel: Immunological aspects of necrotizing enterocolitis models
• Titelzusatz: a review
• Verf.angabe: Laura Blum, Deirdre Vincent, Michael Boettcher and Jasmin Knopf
• E-Jahr: 2024
• Jahr: 22 July 2024
• Umfang: 14 S.
• Fussnoten: Gesehen am 18.11.2024
• Titel Quelle: Enthalten in: Frontiers in immunology
• Ort Quelle: Lausanne : Frontiers Media, 2010
• Jahr Quelle: 2024
• Band/Heft Quelle: 15(2024) vom: 22. Juli, Artikel-ID 1434281, Seite 1-14
• ISSN Quelle: 1664-3224
• DOI: doi:10.3389/fimmu.2024.1434281
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Animal Models
• Sach-SW: immune cells
• Sach-SW: Immune System
• Sach-SW: necrotizing enterocolitis
• Sach-SW: Organoids
• K10plus-PPN: 1908898860
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

<p>Necrotizing enterocolitis (NEC) is one of the most devasting diseases affecting preterm neonates. However, despite a lot of research, NEC’s pathogenesis remains unclear. It is known that the pathogenesis is a multifactorial process, including (1) a pathological microbiome with abnormal bacterial colonization, (2) an immature immune system, (3) enteral feeding, (3) an impairment of microcirculation, and (4) possibly ischemia-reperfusion damage to the intestine. Overall, the immaturity of the mucosal barrier and the increased expression of Toll-like receptor 4 (TLR4) within the intestinal epithelium result in an intestinal hyperinflammation reaction. Concurrently, a deficiency in counter-regulatory mediators can be seen. The sum of these processes can ultimately result in intestinal necrosis leading to very high mortality rates of the affected neonates. In the last decade no substantial advances in the treatment of NEC have been made. Thus, NEC animal models as well as <italic>in vitro</italic> models have been employed to better understand NEC’s pathogenesis on a cellular and molecular level. This review will highlight the different models currently in use to study immunological aspects of NEC.</p>