Peripheral inflammation featuring eosinophilia or neutrophilia is associated with the survival and infiltration of eosinophils within the tumor among various histological subgroups of patients with NSCLC

• Verfasst von: Alashkar Alhamwe, Bilal [VerfasserIn]
• Verfasst von: Yuskaeva, Kadriya [VerfasserIn]
• Verfasst von: Wulf, Friederike [VerfasserIn]
• Verfasst von: Trinkmann, Frederik [VerfasserIn]
• Verfasst von: Kriegsmann, Mark [VerfasserIn]
• Verfasst von: Thomas, Michael [VerfasserIn]
• Verfasst von: Keber, Corinna Ulrike [VerfasserIn]
• Verfasst von: Pogge von Strandmann, Elke [VerfasserIn]
• Verfasst von: Herth, Felix [VerfasserIn]
• Verfasst von: Kolahian, Saeed [VerfasserIn]
• Verfasst von: Renz, Harald [VerfasserIn]
• Verfasst von: Muley, Thomas [VerfasserIn]
• Titel: Peripheral inflammation featuring eosinophilia or neutrophilia is associated with the survival and infiltration of eosinophils within the tumor among various histological subgroups of patients with NSCLC
• Verf.angabe: Bilal Alashkar Alhamwe, Kadriya Yuskaeva, Friederike Wulf, Frederik Trinkmann, Mark Kriegsmann, Michael Thomas, Corinna Ulrike Keber, Elke Pogge von Strandmann, Felix J. Herth, Saeed Kolahian, Harald Renz andThomas Muley
• E-Jahr: 2024
• Jahr: 3 September 2024
• Umfang: 16 S.
• Fussnoten: Gesehen am 19.11.2024
• Titel Quelle: Enthalten in: International journal of molecular sciences
• Ort Quelle: Basel : Molecular Diversity Preservation International, 2000
• Jahr Quelle: 2024
• Band/Heft Quelle: 25(2024), 17, Artikel-ID 9552, Seite 1-16
• ISSN Quelle: 1422-0067
• ISSN Quelle: 1661-6596
• DOI: doi:10.3390/ijms25179552
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: eosinophilia and neutrophilia
• Sach-SW: eosinophils-tumor infiltration
• Sach-SW: lung adenocarcinoma
• Sach-SW: lung non-adenocarcinoma
• Sach-SW: prognosis
• K10plus-PPN: 1908931906

Abstract

Immune activation status determines non-small cell lung cancer (NSCLC) prognosis, with reported positive/negative associations for T helper type 2 (TH2) responses, including allergen-specific IgE and eosinophils. Our study seeks to explore the potential impact of these comorbid immune responses on the survival rates of patients with NSCLC. Our retrospective study used data from the Data Warehouse of the German Center for Lung Research (DZL) and Lung Biobank at Thoraxklinik Heidelberg. We estimated the association of blood eosinophilia and neutrophilia on survival rates in an inflammatory cohort of 3143 patients with NSCLC. We also tested sensitization to food and inhalants and high-sensitivity C-reactive protein (hs-CRP) in a comorbidity cohort of 212 patients with NSCLC. Finally, we estimated the infiltration of immune-relevant cells including eosinophils, T-cells, and mast cells in a tissue inflammatory sub-cohort of 60 patients with NSCLC. Sensitization to at least one food or inhalant (sIgE) was higher in patients with adenocarcinoma (adeno-LC) than the non-adenocarcinoma (non-adeno-LC). Furthermore, hs-CRP was higher in non-adeno-LC compared with adeno-LC. Peripheral inflammation, particularly eosinophilia and neutrophilia, was associated with poor survival outcomes in NSCLC with a clear difference between histological subgroups. Finally, blood eosinophilia was paralleled by significant eosinophil infiltration into the peritumoral tissue in the lung. This study provides novel perspectives on the crucial role of peripheral inflammation, featuring eosinophilia and neutrophilia, with overall survival, underscoring distinctions between NSCLC subgroups (adeno-LC vs. non-adeno-LC). Peripheral eosinophilia enhances eosinophil infiltration into tumors. This sheds light on the complex interplay between inflammation, eosinophil infiltration, and NSCLC prognosis among various histological subtypes. Further studies are required to underscore the role of eosinophils in NSCLC among different histological subgroups and their role in shaping the tumor microenvironment.