Gold catalysis in quinoline synthesis

• Verfasst von: Zhao, Ximei [VerfasserIn]
• Verfasst von: Wang, Guanghui [VerfasserIn]
• Verfasst von: Hashmi, A. Stephen K. [VerfasserIn]
• Titel: Gold catalysis in quinoline synthesis
• Verf.angabe: Ximei Zhao, Guanghui Wang and A. Stephen K. Hashmi
• E-Jahr: 2024
• Jahr: 14 Jun 2024
• Umfang: 18 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 19.11.2024
• Titel Quelle: Enthalten in: Chemical communications
• Ort Quelle: Cambridge : Soc., 1965
• Jahr Quelle: 2024
• Band/Heft Quelle: 60(2024), 55, Seite 6999-7016
• ISSN Quelle: 1364-548X
• DOI: doi:10.1039/D4CC01915F
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 190895289X

Abstract

Quinolines are biologically and pharmaceutically important N-heterocyclic aromatic compounds, which have broad applications in medicinal chemistry. Thus, their efficient synthesis has attracted extensive attention, and a broad range of synthetic strategies have been established. Of note, gold-catalyzed methodologies for the synthesis of quinolines have greatly advanced this field. Various gold-catalyzed intermolecular annulation reactions, such as annulations of aniline derivatives with carbonyl compounds or alkynes, annulations of anthranils with alkynes, and annulations based on A3-coupling reactions, as well as intramolecular cyclization reactions of azide-tethered alkynes, 1,2-diphenylethynes, and 2-ethynyl N-aryl indoles, have been developed. This review provides an overview of this exciting research area. Typical achievements in reaction methodologies and plausible reaction mechanisms are summarized.