Cancer detection rate of breast-MR in supplemental screening after negative mammography in women with dense breasts

• Verfasst von: Kaiser, Clemens G. [VerfasserIn]
• Verfasst von: Wilhelm, T. [VerfasserIn]
• Verfasst von: Walter, Sabrina [VerfasserIn]
• Verfasst von: Singer, Shereen [VerfasserIn]
• Verfasst von: Keller, E. [VerfasserIn]
• Verfasst von: Baltzer, P. A. T. [VerfasserIn]
• Titel: Cancer detection rate of breast-MR in supplemental screening after negative mammography in women with dense breasts
• Titelzusatz: preliminary results of the MA-DETECT-study after 200 participants
• Verf.angabe: CGN Kaiser, T. Wilhelm, S. Walter, S. Singer, E. Keller, P.A.T. Baltzer
• E-Jahr: 2024
• Jahr: July 2024
• Umfang: 19 S.
• Illustrationen: Illustrationen
• Fussnoten: Online verfügbar: 29. April 2024, Artikelversion: 5. Mai 2024 ; Gesehen am 21.11.2024
• Titel Quelle: Enthalten in: European journal of radiology
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1990
• Jahr Quelle: 2024
• Band/Heft Quelle: 176(2024) vom: Juli, Artikel-ID 111476, Seite 1-19
• ISSN Quelle: 1872-7727
• DOI: doi:10.1016/j.ejrad.2024.111476
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1909312177

Abstract

BACKGROUND - Due to increased cancer detection rates (CDR), breast MR (breast MRI) can reduce underdiagnosis of breast cancer compared to conventional imaging techniques, particularly in women with dense breasts. The purpose of this study is to report the additional breast cancer yield by breast MRI in women with dense breasts after receiving a negative screening mammogram. - METHODS - For this study we invited consecutive participants of the national German breast cancer Screening program with breast density categories ACR C & D and a negative mammogram to undergo additional screening by breast MRI. Endpoints were CDR and recall rates. This study reports interim results in the first 200 patients. At a power of 80% and considering an alpha error of 5%, this preliminary population size is sufficient to demonstrate a 4/1000 improvement in CDR. - RESULTS - In 200 screening participants, 8 women (40/1000, 17.4-77.3/1000) were recalled due to positive breast MRI findings. Image-guided biopsy revealed 5 cancers in 4 patients (one bilateral), comprising four invasive cancers and one case of DCIS. 3 patients revealed 4 invasive cancers presenting with ACR C breast density and one patient non-calcifying DCIS in a woman with ACR D breast density, resulting in a CDR of 20/1000 (95%-CI 5.5-50.4/1000) and a PPV of 50% (95%-CI 15.7-84.3%). - CONCLUSION - Our initial results demonstrate that supplemental screening using breast MRI in women with heterogeneously dense and very dense breasts yields an additional cancer detection rate in line with a prior randomized trial on breast MRI screening of women with extremely dense breasts. These findings are highly important as the population investigated constitutes a much higher proportion of women and yielded cancers particularly in women with heterogeneously dense breasts.