Status: Bibliographieeintrag
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| Verfasst von: | Bokelmann, Björn [VerfasserIn]  |
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| | Rauch, Geraldine [VerfasserIn] |
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| | Meis, Jan [VerfasserIn] |
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| | Kieser, Meinhard [VerfasserIn] |
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| | Herrmann, Carolin [VerfasserIn] |
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| Titel: | Extension of a conditional performance score for sample size recalculation rules to the setting of binary endpoints |
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| Verf.angabe: | Björn Bokelmann, Geraldine Rauch, Jan Meis, Meinhard Kieser and Carolin Herrmann |
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| E-Jahr: | 2024 |
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| Jahr: | 19 January 2024 |
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| Umfang: | 14 S. |
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| Illustrationen: | Diagramme |
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| Fussnoten: | Gesehen am 21.11.2024 |
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| Titel Quelle: | Enthalten in: BMC medical research methodology |
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| Ort Quelle: | London : BioMed Central, 2001 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 24(2024), 1, Artikel-ID 15, Seite 1-14 |
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| ISSN Quelle: | 1471-2288 |
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| Abstract: | Sample size calculation is a central aspect in planning of clinical trials. The sample size is calculated based on parameter assumptions, like the treatment effect and the endpoint’s variance. A fundamental problem of this approach is that the true distribution parameters are not known before the trial. Hence, sample size calculation always contains a certain degree of uncertainty, leading to the risk of underpowering or oversizing a trial. One way to cope with this uncertainty are adaptive designs. Adaptive designs allow to adjust the sample size during an interim analysis. There is a large number of such recalculation rules to choose from. To guide the choice of a suitable adaptive design with sample size recalculation, previous literature suggests a conditional performance score for studies with a normally distributed endpoint. However, binary endpoints are also frequently applied in clinical trials and the application of the conditional performance score to binary endpoints is not yet investigated. |
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| DOI: | doi:10.1186/s12874-024-02150-4 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1186/s12874-024-02150-4 |
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| | kostenfrei: Volltext: https://bmcmedresmethodol.biomedcentral.com/articles/10.1186/s12874-024-02150-4 |
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| | DOI: https://doi.org/10.1186/s12874-024-02150-4 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Adaptive designs |
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| | Binary endpoint |
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| | Performance score |
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| | Sample size recalculation |
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| K10plus-PPN: | 1909321133 |
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| Verknüpfungen: | → Zeitschrift |
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Extension of a conditional performance score for sample size recalculation rules to the setting of binary endpoints / Bokelmann, Björn [VerfasserIn]; 19 January 2024 (Online-Ressource)
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