| |  Online-Ressource |
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| Verfasst von: | Jung, Yoon-Seok [VerfasserIn]  |
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| | Radhakrishnan, Kamalakannan [VerfasserIn] |
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| | Hammad, Seddik [VerfasserIn] |
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| | Mueller, Sebastian [VerfasserIn] |
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| | Müller, Johannes [VerfasserIn] |
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| | Noh, Jung-Ran [VerfasserIn] |
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| | Kim, Jina [VerfasserIn] |
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| | Lee, In-Kyu [VerfasserIn] |
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| | Cho, Sung Jin [VerfasserIn] |
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| | Kim, Don-Kyu [VerfasserIn] |
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| | Kim, Yong-Hoon [VerfasserIn] |
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| | Lee, Chul-Ho [VerfasserIn] |
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| | Dooley, Steven [VerfasserIn] |
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| | Choi, Hueng-Sik [VerfasserIn] |
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| Titel: | ERRγ-inducible FGF23 promotes alcoholic liver injury through enhancing CYP2E1 mediated hepatic oxidative stress |
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| Verf.angabe: | Yoon Seok Jung, Kamalakannan Radhakrishnan, Seddik Hammad, Sebastian Müller, Johannes Müller, Jung-Ran Noh, Jina kim, In-Kyu Lee, Sung Jin Cho, Don-Kyu Kim, Yong-Hoon Kim, Chul-Ho Lee, Steven Dooley, Hueng-Sik Choi |
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| E-Jahr: | 2024 |
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| Jahr: | May 2024 |
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| Umfang: | 12 S. |
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| Fussnoten: | Online veröffentlicht: 5. März 2024 ; Gesehen am 25.11.2024 |
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| Titel Quelle: | Enthalten in: Redox Biology |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier, 2013 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 71(2024), Artikel-ID 103107, Seite 103107-1-103107-12 |
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| ISSN Quelle: | 2213-2317 |
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| Abstract: | Fibroblast growth factor 23 (FGF23) is a member of endocrine FGF family, along with FGF15/19 and FGF21. Recent reports showed that under pathological conditions, liver produces FGF23, although the role of hepatic FGF23 remains nebulous. Here, we investigated the role of hepatic FGF23 in alcoholic liver disease (ALD) and delineated the underlying molecular mechanism. FGF23 expression was compared in livers from alcoholic hepatitis patients and healthy controls. The role of FGF23 was examined in hepatocyte-specific knock-out (LKO) mice of cannabinoid receptor type 1 (CB1R), estrogen related receptor γ (ERRγ), or FGF23. Animals were fed with an alcohol-containing liquid diet alone or in combination with ERRγ inverse agonist. FGF23 is mainly expressed in hepatocytes in the human liver, and it is upregulated in ALD patients. In mice, chronic alcohol feeding leads to liver damage and induced FGF23 in liver, but not in other organs. FGF23 is transcriptionally regulated by ERRγ in response to alcohol-mediated activation of the CB1R. Alcohol induced upregulation of hepatic FGF23 and plasma FGF23 levels is lost in ERRγ-LKO mice, and an inverse agonist mediated inhibition of ERRγ transactivation significantly improved alcoholic liver damage. Moreover, hepatic CYP2E1 induction in response to alcohol is FGF23 dependent. In line, FGF23-LKO mice display decreased hepatic CYP2E1 expression and improved ALD through reduced hepatocyte apoptosis and oxidative stress. We recognized CBIR-ERRγ-FGF23 axis in facilitating ALD pathology through hepatic CYP2E1 induction. Thus, we propose FGF23 as a potential therapeutic target to treat ALD. |
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| DOI: | doi:10.1016/j.redox.2024.103107 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.redox.2024.103107 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S2213231724000831 |
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| | DOI: https://doi.org/10.1016/j.redox.2024.103107 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Alcoholic liver disease |
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| | CYP2E1 |
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| | ERRγ |
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| | FGF23 |
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| | Oxidative stress |
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| K10plus-PPN: | 1909428655 |
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| Verknüpfungen: | → Zeitschrift |
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ERRγ-inducible FGF23 promotes alcoholic liver injury through enhancing CYP2E1 mediated hepatic oxidative stress / Jung, Yoon-Seok [VerfasserIn]; May 2024 (Online-Ressource)
