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| Verfasst von: | Gao, Qi [VerfasserIn]  |
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| | Vermeulen, Bram J. A. [VerfasserIn] |
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| | Würtz, Martin [VerfasserIn] |
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| | Shin, Hyesu [VerfasserIn] |
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| | Erdogdu, Dilara [VerfasserIn] |
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| | Zheng, Anjun [VerfasserIn] |
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| | Hofer, Florian W. [VerfasserIn] |
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| | Neuner, Annett [VerfasserIn] |
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| | Pfeffer, Stefan [VerfasserIn] |
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| | Schiebel, Elmar [VerfasserIn] |
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| Titel: | The structure of the γ-TuRC at the microtubule minus end |
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| Titelzusatz: | not just one solution |
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| Verf.angabe: | Qi Gao, Bram J. A. Vermeulen, Martin Würtz, Hyesu Shin, Dilara Erdogdu, Anjun Zheng, Florian W. Hofer, Annett Neuner, Stefan Pfeffer, Elmar Schiebel |
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| E-Jahr: | 2024 |
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| Jahr: | 23 July 2024 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 15.11.2024 |
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| Titel Quelle: | Enthalten in: Bioessays |
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| Ort Quelle: | New York, NY : Wiley-Liss, 1984 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 46(2024), 9, Artikel-ID 2400117, Seite 1-11 |
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| ISSN Quelle: | 1521-1878 |
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| Abstract: | In cells, microtubules (MTs) assemble from α/β-tubulin subunits at nucleation sites containing the γ-tubulin ring complex (γ-TuRC). Within the γ-TuRC, exposed γ-tubulin molecules act as templates for MT assembly by interacting with α/β-tubulin. The vertebrate γ-TuRC is scaffolded by γ-tubulin-interacting proteins GCP2-6 arranged in a specific order. Interestingly, the γ-tubulin molecules in the γ-TuRC deviate from the cylindrical geometry of MTs, raising the question of how the γ-TuRC structure changes during MT nucleation. Recent studies on the structure of the vertebrate γ-TuRC attached to the end of MTs came to varying conclusions. In vitro assembly of MTs, facilitated by an α-tubulin mutant, resulted in a closed, cylindrical γ-TuRC showing canonical interactions between all γ-tubulin molecules and α/β-tubulin subunits. Conversely, native MTs formed in a frog extract were capped by a partially closed γ-TuRC, with some γ-tubulin molecules failing to align with α/β-tubulin. This review discusses these outcomes, along with the broader implications. |
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| DOI: | doi:10.1002/bies.202400117 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1002/bies.202400117 |
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| | kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/bies.202400117 |
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| | DOI: https://doi.org/10.1002/bies.202400117 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | centrosome |
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| | CM1 motif |
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| | cryo-electron microscopy |
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| | microtubule minus end |
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| | nucleation |
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| | spindle-pole body |
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| | γ-tubulin complexes |
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| K10plus-PPN: | 1909433322 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ structure of the γ-TuRC at the microtubule minus end / Gao, Qi [VerfasserIn]; 23 July 2024 (Online-Ressource)
