Psilocybin administered following extinction sessions does not affect subsequent cocaine cue reinstatement in male and female rats and mice

• Verfasst von: Pohořalá, Veronika [VerfasserIn]
• Verfasst von: Kuchař, Martin [VerfasserIn]
• Verfasst von: Spanagel, Rainer [VerfasserIn]
• Verfasst von: Bernardi, Rick E. [VerfasserIn]
• Titel: Psilocybin administered following extinction sessions does not affect subsequent cocaine cue reinstatement in male and female rats and mice
• Verf.angabe: Veronika Pohořalá, Martin Kuchař, Rainer Spanagel, Rick E. Bernardi
• E-Jahr: 2024
• Jahr: 1 November 2024
• Umfang: 10 S.
• Illustrationen: Illustrationen
• Fussnoten: Online verfügbar: 3. September 2024, Artikelversion: 10. September 2024 ; Gesehen am 25.11.2024
• Titel Quelle: Enthalten in: Neuroscience
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1976
• Jahr Quelle: 2024
• Band/Heft Quelle: 559(2024), Seite 156-165
• ISSN Quelle: 1873-7544
• DOI: doi:10.1016/j.neuroscience.2024.09.006
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Addiction
• Sach-SW: Cocaine self-administration
• Sach-SW: Mice
• Sach-SW: Psilocybin
• Sach-SW: Rats
• Sach-SW: Reinstatement
• K10plus-PPN: 1909445576

Abstract

There are currently no pharmacological treatments for cocaine use disorder. Recently there has been a great deal of interest in the potential of psychedelic drugs such as psilocybin to treat psychiatric disorders. Human studies have indicated that a single administration of psilocybin can have long-lasting effects. Few preclinical studies have examined a role for psilocybin in addiction models. The goal of the current study was to determine whether psilocybin would enhance extinction following cocaine self-administration in male and female mice and rats and thus result in an attenuation of cue-induced drug-seeking. In experiments in mice, 16 female and 19 male mice underwent 8d of cocaine self-administration (0.5 mg/kg/infusion) and extinction training. Immediately following extinction trials, mice were injected with vehicle or 1.0 mg/kg psilocybin. Following the conclusion of extinction training, mice were tested for cue-induced reinstatement. In experiments in rats, 24 female and 23 male rats underwent 15d of cocaine self-administration (0.8 mg/kg/infusion) and extinction training. Immediately following extinction trials, rats were injected with vehicle, 1.0 mg/kg psilocybin, or 2.5 mg/kg psilocybin. Following the conclusion of extinction training, rats were tested for cue-induced reinstatement. Psilocybin administered following extinction trials had no effect, as both female and male mice and rats demonstrated significant cue-induced reinstatement. These data suggest that psilocybin is ineffective at altering cocaine-seeking behavior in the paradigm and doses used in the current study. It remains to be seen whether treatment with psilocybin under different conditions may be useful in the long-standing goal of finding pharmacotherapies to treat CUD.