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Verfasst von:Huth, Alina [VerfasserIn]   i
 Ayoub, Ikram [VerfasserIn]   i
 Barateau, Lucie [VerfasserIn]   i
 Gerdes, Lisa Ann [VerfasserIn]   i
 Severac, Dany [VerfasserIn]   i
 Krebs, Stefan [VerfasserIn]   i
 Blum, Helmut [VerfasserIn]   i
 Tumani, Hayrettin [VerfasserIn]   i
 Haas, Jürgen [VerfasserIn]   i
 Wildemann, Brigitte [VerfasserIn]   i
 Kümpfel, Tania [VerfasserIn]   i
 Beltrán, Eduardo [VerfasserIn]   i
 Liblau, Roland S. [VerfasserIn]   i
 Dauvilliers, Yves [VerfasserIn]   i
 Dornmair, Klaus [VerfasserIn]   i
Titel:Single cell transcriptomics of cerebrospinal fluid cells from patients with recent-onset narcolepsy
Verf.angabe:Alina Huth, Ikram Ayoub, Lucie Barateau, Lisa Ann Gerdes, Dany Severac, Stefan Krebs, Helmut Blum, Hayrettin Tumani, Jürgen Haas, Brigitte Wildemann, Tania Kümpfel, Eduardo Beltrán, Roland S. Liblau, Yves Dauvilliers, Klaus Dornmair
E-Jahr:2024
Jahr:24 April 2024
Umfang:12 S.
Fussnoten:Gesehen am 25.11.2024
Titel Quelle:Enthalten in: Journal of autoimmunity
Ort Quelle:[Amsterdam] : Elsevier, 1988
Jahr Quelle:2024
Band/Heft Quelle:146(2024), Artikel-ID 103234, Seite 103234-1-103234-12
ISSN Quelle:1095-9157
Abstract:Narcolepsy is a rare cause of hypersomnolence and may be associated or not with cataplexy, i.e. sudden muscle weakness. These forms are designated narcolepsy-type 1 (NT1) and -type 2 (NT2), respectively. Notable characteristics of narcolepsy are that most patients carry the HLA-DQB1*06:02 allele and NT1-patients have strongly decreased levels of hypocretin-1 (synonym orexin-A) in the cerebrospinal fluid (CSF). The pathogenesis of narcolepsy is still not completely understood but the strong HLA-bias and increased frequencies of CD4+ T cells reactive to hypocretin in the peripheral blood suggest autoimmune processes in the hypothalamus. Here we analyzed the transcriptomes of CSF-cells from twelve NT1 and two NT2 patients by single cell RNAseq (scRNAseq). As controls, we used CSF cells from patients with multiple sclerosis, radiologically isolated syndrome, and idiopathic intracranial hypertension. From 27,255 CSF cells, we identified 20 clusters of different cell types and found significant differences in three CD4+ T cell and one monocyte clusters between narcolepsy and multiple sclerosis patients. Over 1000 genes were differentially regulated between patients with NT1 and other diseases. Surprisingly, the most strongly upregulated genes in narcolepsy patients as compared to controls were coding for the genome-encoded MTRNR2L12 and MTRNR2L8 peptides, which are homologous to the mitochondria-encoded HUMANIN peptide that is known playing a role in other neurological diseases including Alzheimer's disease.
DOI:doi:10.1016/j.jaut.2024.103234
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.jaut.2024.103234
 Volltext: https://www.sciencedirect.com/science/article/pii/S0896841124000684
 DOI: https://doi.org/10.1016/j.jaut.2024.103234
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Cerebrospinal fluid (CSF)
 Narcolepsy
 Single-cell RNA sequencing (scRNAseq)
 T cells
 Transcriptomics
K10plus-PPN:1909447668
Verknüpfungen:→ Zeitschrift

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