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| Verfasst von: | Unger Avila, Paula [VerfasserIn]  |
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| | Padvitski, Tsimafei [VerfasserIn] |
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| | Leote, Ana Carolina [VerfasserIn] |
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| | Chen, He [VerfasserIn] |
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| | Sáez Rodríguez, Julio [VerfasserIn] |
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| | Kann, Martin [VerfasserIn] |
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| | Beyer, Andreas [VerfasserIn] |
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| Titel: | Gene regulatory networks in disease and ageing |
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| Verf.angabe: | Paula Unger Avila, Tsimafei Padvitski, Ana Carolina Leote, He Chen, Julio Saez-Rodriguez, Martin Kann, Andreas Beyer |
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| E-Jahr: | 2024 |
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| Jahr: | 12 June 2024 |
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| Umfang: | 15 S. |
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| Fussnoten: | Gesehen am 25.11.2024 |
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| Titel Quelle: | Enthalten in: Nature reviews. Nephrology |
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| Ort Quelle: | Basingstoke : Nature Publishing Group, 2009 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 20(2024), 9, Seite 616-633 |
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| ISSN Quelle: | 1759-507X |
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| Abstract: | The precise control of gene expression is required for the maintenance of cellular homeostasis and proper cellular function, and the declining control of gene expression with age is considered a major contributor to age-associated changes in cellular physiology and disease. The coordination of gene expression can be represented through models of the molecular interactions that govern gene expression levels, so-called gene regulatory networks. Gene regulatory networks can represent interactions that occur through signal transduction, those that involve regulatory transcription factors, or statistical models of gene-gene relationships based on the premise that certain sets of genes tend to be coexpressed across a range of conditions and cell types. Advances in experimental and computational technologies have enabled the inference of these networks on an unprecedented scale and at unprecedented precision. Here, we delineate different types of gene regulatory networks and their cell-biological interpretation. We describe methods for inferring such networks from large-scale, multi-omics datasets and present applications that have aided our understanding of cellular ageing and disease mechanisms. |
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| DOI: | doi:10.1038/s41581-024-00849-7 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s41581-024-00849-7 |
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| | Volltext: https://www.nature.com/articles/s41581-024-00849-7 |
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| | DOI: https://doi.org/10.1038/s41581-024-00849-7 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Computational biology and bioinformatics |
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| | Mechanisms of disease |
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| | Molecular medicine |
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| | Nephrology |
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| | Systems biology |
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| K10plus-PPN: | 1909455725 |
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| Verknüpfungen: | → Zeitschrift |
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Gene regulatory networks in disease and ageing / Unger Avila, Paula [VerfasserIn]; 12 June 2024 (Online-Ressource)
