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Verfasst von:Kirtschig, Gudula [VerfasserIn]   i
 Kinberger, M. [VerfasserIn]   i
 Kreuter, A. [VerfasserIn]   i
 Simpson, R. [VerfasserIn]   i
 Günthert, A. [VerfasserIn]   i
 van Hees, C. [VerfasserIn]   i
 Becker, K. [VerfasserIn]   i
 Ramakers, M. J. [VerfasserIn]   i
 Corazza, M. [VerfasserIn]   i
 Müller, S. [VerfasserIn]   i
 von Seitzberg, S. [VerfasserIn]   i
 Boffa, M. J. [VerfasserIn]   i
 Stein, Raimund [VerfasserIn]   i
 Barbagli, G. [VerfasserIn]   i
 Chi, C. C. [VerfasserIn]   i
 Dauendorffer, J. N. [VerfasserIn]   i
 Fischer, B. [VerfasserIn]   i
 Gaskins, M. [VerfasserIn]   i
 Hiltunen-Back, E. [VerfasserIn]   i
 Höfinger, A. [VerfasserIn]   i
 Köllmann, N. H. [VerfasserIn]   i
 Kühn, H. [VerfasserIn]   i
 Larsen, H. K. [VerfasserIn]   i
 Lazzeri, M. [VerfasserIn]   i
 Mendling, W. [VerfasserIn]   i
 Nikkels, A. F. [VerfasserIn]   i
 Promm, M. [VerfasserIn]   i
 Rall, K. K. [VerfasserIn]   i
 Regauer, S. [VerfasserIn]   i
 Sárdy, M. [VerfasserIn]   i
 Sepp, N. [VerfasserIn]   i
 Thune, T. [VerfasserIn]   i
 Tsiogka, A. [VerfasserIn]   i
 Vassileva, S. [VerfasserIn]   i
 Voswinkel, L. [VerfasserIn]   i
 Wölber, L. [VerfasserIn]   i
 Werner, R. N. [VerfasserIn]   i
Titel:EuroGuiderm guideline on lichen sclerosus
Titelzusatz:treatment of lichen sclerosus : guidelines
Verf.angabe:G. Kirtschig, M. Kinberger, A. Kreuter, R. Simpson, A. Günthert, C. van Hees, K. Becker, M.J. Ramakers, M. Corazza, S. Müller, S. von Seitzberg, M.J. Boffa, R. Stein, G. Barbagli, C.C. Chi, J.N. Dauendorffer, B. Fischer, M. Gaskins, E. Hiltunen-Back, A. Höfinger, N.H. Köllmann, H. Kühn, H.K. Larsen, M. Lazzeri, W. Mendling, A.F. Nikkels, M. Promm, K.K. Rall, S. Regauer, M. Sárdy, N. Sepp, T. Thune, A. Tsiogka, S. Vassileva, L. Voswinkel, L. Wölber, R.N. Werner
E-Jahr:2024
Jahr:October 2024
Umfang:36 S.
Fussnoten:Erstmals veröffentlicht: 01. Juni 2024 ; Gesehen am 25.11.2024
Titel Quelle:Enthalten in: European Academy of Dermatology and VenereologyJournal of the European Academy of Dermatology and Venereology
Ort Quelle:Oxford [u.a.] : Wiley-Blackwell, 1991
Jahr Quelle:2024
Band/Heft Quelle:38(2024), 10 vom: Okt., Seite 1874-1909
ISSN Quelle:1468-3083
Abstract:Introduction Lichen sclerosus (LS) is an inflammatory skin disease affecting all ages. LS typically involves the anogenital site where it causes itching and soreness; it may lead to sexual and urinary dysfunction in females and males; however, it may be asymptomatic. First signs of LS are usually a whitening of the genital skin, sometimes preceded by redness and oedema; fissuring, scarring, shrinkage and fusion of structures may follow in its course. LS is associated with an increased risk of genital cancer. LS has a huge impact on the quality of life of affected patients, and it is important to raise more awareness of this not uncommon disease in order to diagnose and treat it early. Objectives The guideline intends to provide guidance on the diagnostic of LS (part 1), highlight important aspects in the care of LS patients, generate recommendations and treatment algorithms (part 2) on topical, interventional and surgical therapy, based on the latest evidence, provide guidance in the management of LS patients during pregnancy, provide guidance for the follow-up of patients with LS and inform about new developments and potential research aspects. Materials and Methods The guideline was developed in accordance with the EuroGuiDerm Methods Manual v1.3 https://www.edf.one/de/home/Guidelines/EDF-EuroGuiDerm.html. The wording of the recommendations was standardized (as suggested by the GRADE Working Group). The guideline development group is comprised of 34 experts from 16 countries, including 5 patient representatives. Results Ultrapotent or potent topical corticosteroids in females and males, adults and children remain gold standard of care for genital LS; co-treatment with emollients is recommended. If standard treatment fails in males, a surgical intervention is recommended, complete circumcision may cure LS in males. UV light treatment is recommended for extragenital LS; however, there is limited scientific evidence. Topical calcineurin inhibitors are second line treatment. Laser treatment, using various wave lengths, is under investigation, and it can currently not be recommended for the treatment of LS. Treatment with biologics is only reported in single cases. Conclusions LS has to be diagnosed and treated as early as possible in order to minimize sequelae like scarring and cancer development. Topical potent and ultrapotent corticosteroids are the gold standard of care; genital LS is often a lifelong disease and needs to be treated long-term.
DOI:doi:10.1111/jdv.20083
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1111/jdv.20083
 Volltext: http://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.20083
 DOI: https://doi.org/10.1111/jdv.20083
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1909471968
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