Navigation überspringen
Universitätsbibliothek Heidelberg
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Saber, Mahshid [VerfasserIn]   i
 Kaiser, Michaela [VerfasserIn]   i
 Rüttiger, Lukas [VerfasserIn]   i
 Körber, Christoph [VerfasserIn]   i
Titel:Effects of the two-pore potassium channel subunit Task5 on neuronal function and signal processing in the auditory brainstem
Verf.angabe:Mahshid Helia Saber, Michaela Kaiser, Lukas Rüttiger and Christoph Körber
E-Jahr:2024
Jahr:01 November 2024
Umfang:13 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 26.11.2024
Titel Quelle:Enthalten in: Frontiers in cellular neuroscience
Ort Quelle:Lausanne : Frontiers Research Foundation, 2007
Jahr Quelle:2024
Band/Heft Quelle:18(2024) vom: Nov., Artikel-ID 1463816, Seite 1-13
ISSN Quelle:1662-5102
Abstract:<p>Processing of auditory signals critically depends on the neuron’s ability to fire brief, precisely timed action potentials (APs) at high frequencies and high fidelity for prolonged times. This requires the expression of specialized sets of ion channels to quickly repolarize neurons, prevent aberrant AP firing and tightly regulate neuronal excitability. Although critically important, the regulation of neuronal excitability has received little attention in the auditory system. Neuronal excitability is determined to a large extent by the resting membrane potential (RMP), which in turn depends on the kind and number of ion channels open at rest; mostly potassium channels. A large part of this resting potassium conductance is carried by two-pore potassium channels (K2P channels). Among the K2P channels, the subunit Task5 is expressed almost exclusively in the auditory brainstem, suggesting a specialized role in auditory processing. However, since it failed to form functional ion channels in heterologous expression systems, it was classified “non-functional” for a long time and its role in the auditory system remained elusive. Here, we generated Task5 knock-out (KO) mice. The loss of Task5 resulted in changes in neuronal excitability in bushy cells of the ventral cochlear nucleus (VCN) and principal neurons of the medial nucleus of the trapezoid body (MNTB). Moreover, auditory brainstem responses (ABRs) to loud sounds were altered in Tasko5-KO mice. Thus, our study provides evidence that Task5 is indeed a functional K2P subunit and contributes to sound processing in the auditory brainstem.</p>
DOI:doi:10.3389/fncel.2024.1463816
URL:kostenfrei: Volltext: https://doi.org/10.3389/fncel.2024.1463816
 kostenfrei: Volltext: https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2024.1463816/full
 DOI: https://doi.org/10.3389/fncel.2024.1463816
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:ABR
 Auditory system
 Bushy cells
 Cochlear Nucleus
 MNTB
 stellate cells
K10plus-PPN:1909578444
Verknüpfungen:→ Zeitschrift
 
 
Lokale URL UB: Zum Volltext

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/69277227   QR-Code
zum Seitenanfang