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| Verfasst von: | Ülgen, Ege [VerfasserIn]  |
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| | Gerlevik, Umut [VerfasserIn] |
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| | Gerlevik, Sıla [VerfasserIn] |
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| | Oktay, Yavuz [VerfasserIn] |
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| | Sezerman, Osman Uğur [VerfasserIn] |
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| | Turcan, S̨evin [VerfasserIn] |
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| | Ozduman, Koray [VerfasserIn] |
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| Titel: | A microdeletion event at 19q13.43 in IDH-mutant astrocytomas is strongly correlated with MYC overexpression |
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| Verf.angabe: | Ege Ülgen, Umut Gerlevik, Sıla Gerlevik, Yavuz Oktay, Osman Uğur Sezerman, Şevin Turcan and Koray Ozduman |
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| E-Jahr: | 2024 |
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| Jahr: | 14 June 2024 |
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| Umfang: | 11 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 27.11.2024 |
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| Titel Quelle: | Enthalten in: Acta Neuropathologica Communications |
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| Ort Quelle: | London : Biomed Central, 2013 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 12(2024), Artikel-ID 95, Seite 1-11 |
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| ISSN Quelle: | 2051-5960 |
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| Abstract: | MYC dysregulation is pivotal in the onset and progression of IDH-mutant gliomas, mostly driven by copy-number alterations, regulatory element alterations, or epigenetic changes. Our pilot analysis uncovered instances of relative MYC overexpression without alterations in the proximal MYC network (PMN), prompting a deeper investigation into potential novel oncogenic mechanisms. Analysing comprehensive genomics profiles of 236 “IDH-mutant 1p/19q non-co-deleted” lower-grade gliomas from The Cancer Genome Atlas, we identified somatic genomic alterations within the PMN. In tumours without PMN-alterations but with MYC-overexpression, genes correlated with MYC-overexpression were identified. Our analyses yielded that 86/236 of astrocytomas exhibited no PMN-alterations, a subset of 21/86 displaying relative MYC overexpression. Within this subset, we discovered 42 genes inversely correlated with relative MYC expression, all on 19q. Further analysis pinpointed a minimal common region at 19q13.43, encompassing 15 genes. The inverse correlations of these 15 genes with relative MYC overexpression were re-confirmed using independent scRNAseq data. Further, the micro-deleted astrocytoma subset displayed significantly higher genomic instability compared to WT cases, but lower instability compared to PMN-hit cases. This newly identified 19q micro-deletion represents a potential novel mechanism underlying MYC dysregulation in astrocytomas. Given the prominence of 19q loss in IDH-mutant gliomas, our findings bear significant implications for understanding gliomagenesis. |
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| DOI: | doi:10.1186/s40478-024-01811-1 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1186/s40478-024-01811-1 |
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| | DOI: https://doi.org/10.1186/s40478-024-01811-1 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | 19q deletion |
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| | Astrocytoma |
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| | Gliomagenesis |
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| | Integrative analysis |
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| | MYC dysregulation |
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| K10plus-PPN: | 1909623814 |
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| Verknüpfungen: | → Zeitschrift |
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¬A¬ microdeletion event at 19q13.43 in IDH-mutant astrocytomas is strongly correlated with MYC overexpression / Ülgen, Ege [VerfasserIn]; 14 June 2024 (Online-Ressource)
