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Status: Bibliographieeintrag

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Verfasst von:Theilmann, Michaela [VerfasserIn]   i
 Geldsetzer, Pascal [VerfasserIn]   i
 Bärnighausen, Till [VerfasserIn]   i
 Sudharsanan, Nikkil [VerfasserIn]   i
Titel:Does early childhood BCG vaccination improve survival to midlife in a population with a low tuberculosis prevalence?
Titelzusatz:quasi-experimental evidence on nonspecific effects from 32 Swedish birth cohorts
Verf.angabe:Michaela Theilmann, Pascal Geldsetzer, Till Bärnighausen, and Nikkil Sudharsanan
E-Jahr:2023
Jahr:21 September 2023
Umfang:24 S.
Fussnoten:Gesehen am 27.11.2024
Titel Quelle:Enthalten in: Demography
Ort Quelle:Austin : DUKE University Press, 1964
Jahr Quelle:2023
Band/Heft Quelle:60(2023), 5 vom: Okt., Seite 1607-1630
ISSN Quelle:1533-7790
Abstract:The Bacillus Calmette-Guérin (BCG) vaccine for tuberculosis (TB) is widely used globally. Many high-income countries discontinued nationwide vaccination policies starting in the 1980s as the TB prevalence decreased. However, there is continued scientific interest in whether the general childhood immunity boost conferred by the BCG vaccination impacts adult health and mortality in low-TB contexts (known as nonspecific effects). While recent studies have found evidence of an association between BCG vaccination and survival to ages 34-45, it is unclear whether these associations are causal or driven by the unobserved characteristics of those who chose to voluntarily vaccinate. We use the abrupt discontinuation of mandatory BCG vaccination in Sweden in 1975 as a natural experiment to estimate the causal nonspecific effect of the BCG vaccine on cohort survival to midlife. Applying two complementary study designs, we find no evidence that survival to age 40 was affected by the discontinuation of childhood BCG vaccination. The results are consistent among both males and females and are robust to several sensitivity tests. Overall, despite prior correlational studies suggesting large nonspecific effects, we do not find any population-level evidence for a nonspecific effect of the BCG vaccine discontinuation on survival to age 40 in Sweden.
DOI:doi:10.1215/00703370-10970757
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1215/00703370-10970757
 kostenfrei: Volltext: https://read.dukeupress.edu/demography/article/60/5/1607/382374
 DOI: https://doi.org/10.1215/00703370-10970757
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:190963073X
Verknüpfungen:→ Zeitschrift

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