RNA-binding proteins in cardiovascular biology and disease

• Verfasst von: Völkers, Mirko [VerfasserIn]
• Verfasst von: Preiss, Thomas [VerfasserIn]
• Verfasst von: Hentze, Matthias W. [VerfasserIn]
• Titel: RNA-binding proteins in cardiovascular biology and disease
• Titelzusatz: the beat goes on
• Verf.angabe: Mirko Völkers, Thomas Preiss, Matthias W. Hentze
• E-Jahr: 2024
• Jahr: June 2024
• Umfang: 18 S.
• Fussnoten: Online veröffentlicht: 2. Januar 2024 ; Gesehen am 28.11.2024
• Titel Quelle: Enthalten in: Nature reviews. Cardiology
• Ort Quelle: Basingstoke : Nature Publishing Group, 2009
• Jahr Quelle: 2024
• Band/Heft Quelle: 21(2024), 6, Seite 361-378
• ISSN Quelle: 1759-5010
• DOI: doi:10.1038/s41569-023-00958-z
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Cardiovascular diseases
• Sach-SW: Molecular biology
• K10plus-PPN: 1909825050

Abstract

Cardiac development and function are becoming increasingly well understood from different angles, including signalling, transcriptional and epigenetic mechanisms. By contrast, the importance of the post-transcriptional landscape of cardiac biology largely remains to be uncovered, building on the foundation of a few existing paradigms. The discovery during the past decade of hundreds of additional RNA-binding proteins in mammalian cells and organs, including the heart, is expected to accelerate progress and has raised intriguing possibilities for better understanding the intricacies of cardiac development, metabolism and adaptive alterations. In this Review, we discuss the progress and new concepts on RNA-binding proteins and RNA biology and appraise them in the context of common cardiovascular clinical conditions, from cell and organ-wide perspectives. We also discuss how a better understanding of cardiac RNA-binding proteins can fill crucial knowledge gaps in cardiology and might pave the way to developing better treatments to reduce cardiovascular morbidity and mortality.