Differences in excess mortality by recipient sex after heart transplant

• Verfasst von: Vinson, Amanda J. [VerfasserIn]
• Verfasst von: Zhang, Xun [VerfasserIn]
• Verfasst von: Dahhou, Mourad [VerfasserIn]
• Verfasst von: Süsal, Caner [VerfasserIn]
• Verfasst von: Döhler, Bernd [VerfasserIn]
• Verfasst von: Melk, Anette [VerfasserIn]
• Verfasst von: Sapir-Pichhadze, Ruth [VerfasserIn]
• Verfasst von: Cardinal, Heloise [VerfasserIn]
• Verfasst von: Wong, Germaine [VerfasserIn]
• Verfasst von: Francis, Anna [VerfasserIn]
• Verfasst von: Pilmore, Helen [VerfasserIn]
• Verfasst von: Grinspan, Lauren T. [VerfasserIn]
• Verfasst von: Foster, Bethany J. [VerfasserIn]
• Titel: Differences in excess mortality by recipient sex after heart transplant
• Titelzusatz: an individual patient data meta-analysis
• Verf.angabe: Amanda J. Vinson, MD, MSc, Xun Zhang, PhD, Mourad Dahhou, MSc, Caner Süsal, MD, Bernd Döhler, PhD, Anette Melk, MD, Ruth Sapir-Pichhadze, MD, MSc, PhD, Heloise Cardinal, MD, PhD, Germaine Wong, MD, Anna Francis, PhD, Helen Pilmore, MD, Lauren T. Grinspan, MD, and Bethany J. Foster, MD, MSc
• E-Jahr: 2024
• Jahr: July 2024
• Umfang: 12 S.
• Illustrationen: Illustrationen
• Fussnoten: Online verfügbar: 24. März 2024, Artikelversion: 30. Mai 2024 ; Gesehen am 29.11.2024
• Titel Quelle: Enthalten in: The journal of heart and lung transplantation
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1999
• Jahr Quelle: 2024
• Band/Heft Quelle: 43(2024), 7 vom: Juli, Seite 1162-1173
• ISSN Quelle: 1557-3117
• DOI: doi:10.1016/j.healun.2024.03.016
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: age
• Sach-SW: gender
• Sach-SW: heart
• Sach-SW: recipient
• Sach-SW: relative excess mortality
• Sach-SW: sex
• Sach-SW: transplantation
• K10plus-PPN: 190991228X

Abstract

Background - Identification of differences in mortality risk between female and male heart transplant recipients may prompt sex-specific management strategies. Because worldwide, males of all ages have higher absolute mortality rates than females, we aimed to compare the excess risk of mortality (risk above the general population) in female vs male heart transplant recipients. - Methods - We used relative survival models conducted separately in SRTR and CTS cohorts from 1988-2019, and subsequently combined using 2-stage individual patient data meta-analysis, to compare the excess risk of mortality in female vs male first heart transplant recipients, accounting for the modifying effects of donor sex and recipient current age. - Results - We analyzed 108,918 patients. When the donor was male, female recipients 0-12 years (Relative excess risk (RER) 1.13, 95% CI 1.00-1.26), 13-44 years (RER 1.17, 95% CI 1.10-1.25), and ≥45 years (RER 1.14, 95% CI 1.02-1.27) showed higher excess mortality risks than male recipients of the same age. When the donor was female, only female recipients 13-44 years showed higher excess risks of mortality than males (RER 1.09, 95% CI 1.00-1.20), though not significantly (p = 0.05). - Conclusions - In the setting of a male donor, female recipients of all ages had significantly higher excess mortality than males. When the donor was female, female recipients of reproductive age had higher excess risks of mortality than male recipients of the same age, though this was not statistically significant. Further investigation is required to determine the reasons underlying these differences.