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| Verfasst von: | Krieg, Sandro [VerfasserIn]  |
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| | Schwendner, Maximilian [VerfasserIn] |
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| | Kram, Leonie [VerfasserIn] |
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| | Zhang, Haosu [VerfasserIn] |
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| | Liang, Raimunde [VerfasserIn] |
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| | Negwer, Chiara [VerfasserIn] |
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| | Meyer, Bernhard [VerfasserIn] |
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| Titel: | Transcranial transmission ultrasound for reliable noninvasive exclusion of intracranial hypertension in traumatic brain injury patients |
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| Titelzusatz: | a proof of concept study |
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| Verf.angabe: | Sandro M. Krieg, Maximilian Schwendner, Leonie Kram, Haosu Zhang, Raimunde Liang, Chiara Negwer, Bernhard Meyer |
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| E-Jahr: | 2024 |
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| Jahr: | 21 October 2024 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 02.12.2024 |
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| Titel Quelle: | Enthalten in: Journal of neurotrauma |
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| Ort Quelle: | Larchmont, NY : Liebert, 1988 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 41(2024), 19-20, Seite 2298-2306 |
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| ISSN Quelle: | 1557-9042 |
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| Abstract: | For many years, noninvasive methods to measure intracranial pressure (ICP) have been unsuccessful. However, such methods are crucial for the assessment of patients with nonpenetrating traumatic brain injuries (TBIs) who are unconscious. In this study, we explored the use of transcranial transmission ultrasound (TTUS) to gather experimental data through brain pulsatility, assessing its effectiveness in detecting high ICP using machine learning analysis. We included patients with severe TBI under invasive ICP monitoring in our intensive care unit. During periods of both normal and elevated ICP, we simultaneously recorded ICP, arterial blood pressure, heart rate, and TTUS measurements. Our classification model was based on data from 9 patients, encompassing 387 instances of elevated ICP (>15 mmHg) and 345 instances of normal ICP (<10 mmHg), and validated through a leave-one-subject-out method. The study, conducted from October 2021 to October 2022, involved 25 patients with an average age of 61.6 ± 17.6 years, producing 279 datasets with an average ICP of 11.3 mmHg (1st quartile 6.1 mmHg; 3rd quartile 14.8 mmHg). The automated TTUS analysis effectively identified ICP values over 15 mmHg with 100% sensitivity and 47% specificity. It achieved a 100% negative predictive value and a 14% positive predictive value. This suggests that TTUS can accurately rule out high ICP above 15 mmHg in TBI patients, indicating patients who may need immediate imaging or intervention. These promising results, if confirmed and expanded in larger studies, could lead to the first reliable, noninvasive screening tool for detecting elevated ICP. |
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| DOI: | doi:10.1089/neu.2024.0027 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1089/neu.2024.0027 |
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| | DOI: https://doi.org/10.1089/neu.2024.0027 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Adult |
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| | Aged |
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| | Aged, 80 and over |
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| | Brain Injuries, Traumatic |
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| | Female |
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| | Humans |
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| | ICP |
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| | Intracranial Hypertension |
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| | Intracranial Pressure |
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| | Male |
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| | Middle Aged |
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| | noninvasive |
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| | Proof of Concept Study |
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| | TBI |
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| | Ultrasonography, Doppler, Transcranial |
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| | ultrasound |
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| K10plus-PPN: | 1910468762 |
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| Verknüpfungen: | → Zeitschrift |
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Transcranial transmission ultrasound for reliable noninvasive exclusion of intracranial hypertension in traumatic brain injury patients / Krieg, Sandro [VerfasserIn]; 21 October 2024 (Online-Ressource)
