| |  Online-Ressource |
|---|
| Verfasst von: | Mujanovic, Adnan [VerfasserIn]  |
|---|
| | Strbian, Daniel [VerfasserIn] |
|---|
| | Demeestere, Jelle [VerfasserIn] |
|---|
| | Marto, João Pedro [VerfasserIn] |
|---|
| | Puetz, Volker [VerfasserIn] |
|---|
| | Nogueira, Raul G [VerfasserIn] |
|---|
| | Abdalkader, Mohamad [VerfasserIn] |
|---|
| | Nagel, Simon [VerfasserIn] |
|---|
| | Raymond, Jean [VerfasserIn] |
|---|
| | Ribo, Marc [VerfasserIn] |
|---|
| | Michel, Patrik [VerfasserIn] |
|---|
| | Yoshimura, Shinichi [VerfasserIn] |
|---|
| | Zaidat, Osama O [VerfasserIn] |
|---|
| | Winzer, Simon [VerfasserIn] |
|---|
| | Ortega-Gutierrez, Santiago [VerfasserIn] |
|---|
| | Sheth, Sunil A [VerfasserIn] |
|---|
| | Siegler, James E [VerfasserIn] |
|---|
| | Dusart, Anne [VerfasserIn] |
|---|
| | Haussen, Diogo C [VerfasserIn] |
|---|
| | Henon, Hilde [VerfasserIn] |
|---|
| | Serrallach, Bettina L [VerfasserIn] |
|---|
| | Mohammaden, Mahmoud H [VerfasserIn] |
|---|
| | Möhlenbruch, Markus Alfred [VerfasserIn] |
|---|
| | Olive-Gadea, Marta [VerfasserIn] |
|---|
| | Puri, Ajit S [VerfasserIn] |
|---|
| | Sakai, Nobuyuki [VerfasserIn] |
|---|
| | Klein, Piers [VerfasserIn] |
|---|
| | Tomppo, Liisa [VerfasserIn] |
|---|
| | Caparros, Francois [VerfasserIn] |
|---|
| | Ramos, João Nuno [VerfasserIn] |
|---|
| | Jumaa, Mouhammad [VerfasserIn] |
|---|
| | Zaidi, Syed [VerfasserIn] |
|---|
| | Dobrocky, Tomas [VerfasserIn] |
|---|
| | Martinez-Majander, Nicolas [VerfasserIn] |
|---|
| | Nannoni, Stefania [VerfasserIn] |
|---|
| | Bellante, Flavio [VerfasserIn] |
|---|
| | Rodriguez-Calienes, Aaron [VerfasserIn] |
|---|
| | Salazar-Marioni, Sergio [VerfasserIn] |
|---|
| | Virtanen, Pekka [VerfasserIn] |
|---|
| | Kaiser, Daniel PO [VerfasserIn] |
|---|
| | Ventura, Rita [VerfasserIn] |
|---|
| | Jesser, Jessica [VerfasserIn] |
|---|
| | Castonguay, Alicia C [VerfasserIn] |
|---|
| | Qureshi, Muhammad M [VerfasserIn] |
|---|
| | Masoud, Hesham E [VerfasserIn] |
|---|
| | Galecio-Castillo, Milagros [VerfasserIn] |
|---|
| | Requena, Manuel [VerfasserIn] |
|---|
| | Lauha, Riikka [VerfasserIn] |
|---|
| | Hu, Wei [VerfasserIn] |
|---|
| | Lin, Eugene [VerfasserIn] |
|---|
| | Miao, Zhongrong [VerfasserIn] |
|---|
| | Roy, Daniel [VerfasserIn] |
|---|
| | Yamagami, Hiroshi [VerfasserIn] |
|---|
| | Seiffge, David J [VerfasserIn] |
|---|
| | Strambo, Davide [VerfasserIn] |
|---|
| | Ringleb, Peter A [VerfasserIn] |
|---|
| | Lemmens, Robin [VerfasserIn] |
|---|
| | Fischer, Urs [VerfasserIn] |
|---|
| | Nguyen, Thanh N [VerfasserIn] |
|---|
| | Kaesmacher, Johannes [VerfasserIn] |
|---|
| Titel: | Safety and clinical outcomes of endovascular therapy versus medical management in late presentation of large ischemic stroke |
|---|
| Verf.angabe: | Adnan Mujanovic, Daniel Strbian, Jelle Demeestere, João Pedro Marto, Volker Puetz, Raul G Nogueira, Mohamad Abdalkader, Simon Nagel, Jean Raymond, Marc Ribo, Patrik Michel, Shinichi Yoshimura, Osama O Zaidat, Simon Winzer, Santiago Ortega-Gutierrez, Sunil A Sheth, James E Siegler, Anne Dusart, Diogo C Haussen, Hilde Henon, Bettina L Serrallach, Mahmoud H Mohammaden, Markus A Möhlenbruch, Marta Olive-Gadea, Ajit S Puri, Nobuyuki Sakai, Piers Klein, Liisa Tomppo, Francois Caparros, João Nuno Ramos, Mouhammad Jumaa, Syed Zaidi, Tomas Dobrocky, Nicolas Martinez-Majander, Stefania Nannoni, Flavio Bellante, Aaron Rodriguez-Calienes, Sergio Salazar-Marioni, Pekka Virtanen, Daniel PO Kaiser, Rita Ventura, Jessica Jesser, Alicia C Castonguay, Muhammad M Qureshi, Hesham E Masoud, Milagros Galecio-Castillo, Manuel Requena, Riikka Lauha, Wei Hu, Eugene Lin, Zhongrong Miao, Daniel Roy, Hiroshi Yamagami, David J Seiffge, Davide Strambo, Peter A Ringleb, Robin Lemmens, Urs Fischer, Thanh N Nguyen, and Johannes Kaesmacher |
|---|
| E-Jahr: | 2024 |
|---|
| Jahr: | May 17, 2024 |
|---|
| Umfang: | 11 S. |
|---|
| Illustrationen: | Illustrationen |
|---|
| Fussnoten: | Gesehen am 02.12.2024 |
|---|
| Titel Quelle: | Enthalten in: European stroke journal |
|---|
| Ort Quelle: | London : Sage Publishing, 2016 |
|---|
| Jahr Quelle: | 2024 |
|---|
| Band/Heft Quelle: | 9(2024), 4 vom: Mai, Seite 907-917 |
|---|
| ISSN Quelle: | 2396-9881 |
|---|
| Abstract: | Introduction: The benefit of endovascular therapy (EVT) among stroke patients with large ischemic core (ASPECTS 0-5) in the extended time window outside of trial settings remains unclear. We analyzed the effect of EVT among these stroke patients in real-world settings. - Patients and methods: The CT for Late Endovascular Reperfusion (CLEAR) study recruited patients from 66 centers in 10 countries between 01/2014 and 05/2022. The extended time-window was defined as 6-24 h from last-seen-well to treatment. The primary outcome was shift of the 3-month modified Rankin scale (mRS) score. Safety outcomes included symptomatic intracranial hemorrhage (sICH) and mortality. Outcomes were analyzed with ordinal and logistic regressions. - Results: Among 5098 screened patients, 2451 were included in the analysis (median age 73, 55% women). Of patients with ASPECTS 0-5 (n = 310), receiving EVT (n = 209/310) was associated with lower 3-month mRS when compared to medical management (median 4 IQR 3-6 vs 6 IQR 4-6; aOR 0.4, 95% CI 0.2-0.7). Patients undergoing EVT had higher sICH (11.2% vs 4.0%; aOR 4.1, 95% CI 1.2-18.8) and lower mortality (31.6% vs 58.4%, aOR 0.4; 95% CI 0.2-0.9) compared to medically managed patients. The relative benefit of EVT was comparable between patients with ASPECTS 0 and 5 and 6-10 in the extended time window (interaction aOR 0.9; 95% CI 0.5-1.7). - Conclusion: In the extended time window, patients with ASPECTS 0-5 may have preserved relative treatment benefit of EVT compared to patients with ASPECTS 6-10. These findings are in line with recent trials showing benefit of EVT among real-world patients with large ischemic core in the extended time window. - Trial registration number: clinicaltrials.gov; Unique identifier: NCT04096248 |
|---|
| DOI: | doi:10.1177/23969873241249406 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1177/23969873241249406 |
|---|
| | DOI: https://doi.org/10.1177/23969873241249406 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| K10plus-PPN: | 1910569836 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Safety and clinical outcomes of endovascular therapy versus medical management in late presentation of large ischemic stroke / Mujanovic, Adnan [VerfasserIn]; May 17, 2024 (Online-Ressource)
