| Online-Ressource |
Verfasst von: | Baumann, J. Ê. [VerfasserIn]  |
| Persson, Pontus B. [VerfasserIn]  |
| Ehmke, Heimo [VerfasserIn]  |
| Nafz, Benno [VerfasserIn]  |
| Kirchheim, Hartmut [VerfasserIn]  |
Titel: | Role of endothelium-derived relaxing factor in renal autoregulation in conscious dogs |
Verf.angabe: | J.E. Baumann, P.B. Persson, H. Ehmke, B. Nafz, H.R. Kirchheim |
E-Jahr: | 1992 |
Jahr: | August 1992 |
Umfang: | 6 S. |
Fussnoten: | Gesehen am 02.12.2024 |
Titel Quelle: | Enthalten in: American journal of physiology. Renal physiology |
Ort Quelle: | Bethesda, Md. : Soc., 1977 |
Jahr Quelle: | 1992 |
Band/Heft Quelle: | 263(1992), 2, Seite F208-F213 |
ISSN Quelle: | 1522-1466 |
Abstract: | In six chronically instrumented, conscious dogs the hypothesis was tested that the release of endothelium-derived relaxing factor (EDRF) is important for autoregulation of renal blood flow (RBF) and glomerular filtration rate (GFR). RBF was measured by a Transonic flowmeter. Renal perfusion pressure was servo-controlled by an aortic cuff. EDRF synthesis was inhibited by NG-nitro-L-arginine methyl ester (L-NAME, 50 mg/kg iv). L-NAME increased mean systemic blood pressure (30 mmHg) and decreased heart rate (-40 beats/min), but it left autoregulation of RBF and GFR intact. However, basal RBF decreased markedly (2.24 +/- 0.32 ml.min-1.g-1 with L-NAME vs. 3.91 +/- 0.64 ml.min-1.g-1 for control, P less than 0.01), whereas basal GFR was not significantly influenced (0.37 +/- 0.05 ml.min-1.g-1 with L-NAME vs. 0.42 +/- 0.06 ml.min-1.g-1 for control). Hence filtration fraction increased with L-NAME [27.6 +/- 1.7% vs. 19.3 +/- 1.3% (P less than 0.01)]. The lower limit of autoregulation remained unchanged for RBF (64 +/- 5 mmHg with L-NAME vs. 63 +/- 3 mmHg for control) and increased slightly for GFR (74 +/- 2 mmHg with L-NAME vs. 67 +/- 1 mmHg for control, P less than 0.01). In conclusion, basal EDRF activity tonically influences renal resistance vessels; however, EDRF release is not primarily involved in the process of renal autoregulation. The maintenance of GFR suggests that this effect is localized in preglomerular as well as in postglomerular arterioles. |
DOI: | doi:10.1152/ajprenal.1992.263.2.F208 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1152/ajprenal.1992.263.2.F208 |
| Volltext: https://journals.physiology.org/doi/abs/10.1152/ajprenal.1992.263.2.F208 |
| DOI: https://doi.org/10.1152/ajprenal.1992.263.2.F208 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1910581763 |
Verknüpfungen: | → Zeitschrift |
Role of endothelium-derived relaxing factor in renal autoregulation in conscious dogs / Baumann, J. Ê. [VerfasserIn]; August 1992 (Online-Ressource)