| |  Online-Ressource |
|---|
| Verfasst von: | Chen, Huijun [VerfasserIn]  |
|---|
| | Liu, Yvonne [VerfasserIn] |
|---|
| | Xu, Xiangwang [VerfasserIn] |
|---|
| | Hu, Liang [VerfasserIn] |
|---|
| | Cai, Sufen [VerfasserIn] |
|---|
| | Gong, Fei [VerfasserIn] |
|---|
| | Lin, Ge [VerfasserIn] |
|---|
| | Kalk, Philipp [VerfasserIn] |
|---|
| | Krämer, Bernhard [VerfasserIn] |
|---|
| | Hocher, Berthold [VerfasserIn] |
|---|
| Titel: | Estradiol-to-follicle ratio on human chorionic gonadotropin day is a novel predictor of gestational diabetes mellitus in women receiving fresh embryo transfer |
|---|
| Verf.angabe: | Huijun Chen, Yvonne Liu, Xiangwang Xu, Liang Hu, Sufen Cai, Fei Gong, Ge Lin, Philipp Kalk, Bernhard K. Krämer and Berthold Hocher |
|---|
| E-Jahr: | 2024 |
|---|
| Jahr: | 11 October 2024 |
|---|
| Umfang: | 9 S. |
|---|
| Fussnoten: | Gesehen am 02.12.2024 |
|---|
| Titel Quelle: | Enthalten in: Frontiers in endocrinology |
|---|
| Ort Quelle: | Lausanne : Frontiers Research Foundation, 2010 |
|---|
| Jahr Quelle: | 2024 |
|---|
| Band/Heft Quelle: | 15(2024) vom: Okt., Artikel-ID 1465069, Seite 1-9 |
|---|
| ISSN Quelle: | 1664-2392 |
|---|
| Abstract: | Aims: To assess the predictive value of estradiol (E2) related parameters on the incidence of gestational diabetes mellitus (GDM) in women undergoing fresh embryo transfer. Materials and methods: A Post-hoc analysis of a prospective cohort study. Results: We identified an optimal E2/follicle (E2/F) ratio threshold of 246.03 pg/ml on the day of human chorionic gonadotropin (hCG) administration. Women with an E2/F ratio exceeding this threshold had significantly lower rates of GDM (12.75% vs. 20.41%, P < 0.001) and ovarian hyperstimulation syndrome (OHSS) (11.75% vs. 15.48%, P = 0.03). Additional E2 parameters were also evaluated: baseline E2, E2 on hCG day, E2 increase, and E2 fold change. Lower GDM rates were observed in women with baseline E2 above 31.50 pg/ml (13.51% vs. 19.42%, P <0.01), E2 on hCG day above 3794.50 pg/ml (12.26% vs. 19.32%, P < 0.001), and E2 increase above 3771.50 pg/ml (12.24% vs. 19.28%, P < 0.001). There were no significant differences in OHSS rates for these additional E2 parameters. After adjusting for confounders, lower E2/F ratio (OR: 1.626, 95% CI: 1.229-2.150, P <0.01), E2 on hCG day (OR: 1.511, 95% CI: 1.133-2.016, P = 0.01), and E2 increase (OR: 1.522, 95% CI: 1.141-2.031, P <0.01) were identified as risk factors for GDM. Conclusion: This study demonstrates that an E2/F ratio over 246.03 pg/ml is significantly associated with a reduced risk of both GDM and OHSS in women undergoing fresh embryo transfer, highlighting the E2/F ratio as a superior predictive biomarker compared to other E2-related parameters. |
|---|
| DOI: | doi:10.3389/fendo.2024.1465069 |
|---|
| URL: | kostenfrei: Volltext: https://doi.org/10.3389/fendo.2024.1465069 |
|---|
| | kostenfrei: Volltext: https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1465069/full |
|---|
| | DOI: https://doi.org/10.3389/fendo.2024.1465069 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Estradiol: follicle ratio |
|---|
| | GDM |
|---|
| | IVF |
|---|
| | predictor |
|---|
| | pregnancy outcomes |
|---|
| K10plus-PPN: | 191058469X |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
| |
|
|---|
| | |
|---|
| Lokale URL UB: |  Zum Volltext |
|---|
Estradiol-to-follicle ratio on human chorionic gonadotropin day is a novel predictor of gestational diabetes mellitus in women receiving fresh embryo transfer / Chen, Huijun [VerfasserIn]; 11 October 2024 (Online-Ressource)
