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Verfasst von:Wenz, Theresa [VerfasserIn]   i
 Altamura, Sandro [VerfasserIn]   i
 Muckenthaler, Martina [VerfasserIn]   i
 Merle, Uta [VerfasserIn]   i
Titel:Hypoferremia is associated with increased hospitalization and oxygen demand in COVID-19 patients
Verf.angabe:Theresa Hippchen, Sandro Altamura, Martina U. Muckenthaler, Uta Merle
E-Jahr:2020
Jahr:10 November 2020
Umfang:9 S.
Illustrationen:Diagramme
Fussnoten:Gesehen am 03.12.2024
Titel Quelle:Enthalten in: HemaSphere
Ort Quelle:Hoboken : John Wiley & Sons Ltd., 2017
Jahr Quelle:2020
Band/Heft Quelle:4(2020), 6 vom: Dez., Artikel-ID e492, Seite 1-9
ISSN Quelle:2572-9241
Abstract:Iron metabolism might play a crucial role in cytokine release syndrome in COVID-19 patients. Therefore, we assessed iron metabolism markers in COVID-19 patients for their ability to predict disease severity. COVID-19 patients referred to the Heidelberg University Hospital were retrospectively analyzed. Patients were divided into outpatients (cohort A, n = 204), inpatients (cohort B, n = 81), and outpatients later admitted to hospital because of health deterioration (cohort C, n = 23). Iron metabolism parameters were severely altered in patients of cohort B and C compared to cohort A. In multivariate regression analysis including age, gender, CRP and iron-related parameters only serum iron and ferritin were significantly associated with hospitalization. ROC analysis revealed an AUC for serum iron of 0.894 and an iron concentration <6 μmol/l as the best cutoff-point predicting hospitalization with a sensitivity of 94.7% and a specificity of 67.9%. When stratifying inpatients in a low- and high oxygen demand group serum iron levels differed significantly between these two groups and showed a high negative correlation with the inflammatory parameters IL-6, procalcitonin, and CRP. Unexpectedly, serum iron levels poorly correlate with hepcidin. We conclude that measurement of serum iron can help predicting the severity of COVID-19. The differences in serum iron availability observed between the low and high oxygen demand group suggest that disturbed iron metabolism likely plays a causal role in the pathophysiology leading to lung injury.
DOI:doi:10.1097/HS9.0000000000000492
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1097/HS9.0000000000000492
 kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1097/HS9.0000000000000492
 DOI: https://doi.org/10.1097/HS9.0000000000000492
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1910673692
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