| Online-Ressource |
Verfasst von: | Persson, Pontus B. [VerfasserIn]  |
| Ehmke, Heimo [VerfasserIn]  |
| Kirchheim, Hartmut [VerfasserIn]  |
| Lempinen, Marko H. [VerfasserIn]  |
| Nafz, Benno [VerfasserIn]  |
Titel: | The role of the kidney in canine blood pressure control |
Titelzusatz: | direct assessment of the closed-loop gain |
Verf.angabe: | P.B. Persson, H. Ehmke, H.R. Kirchheim, M. Lempinen, B. Nafz |
E-Jahr: | 1993 |
Jahr: | 01 May 1993 |
Umfang: | 10 S. |
Fussnoten: | Gesehen am 04.12.2024 |
Titel Quelle: | Enthalten in: The journal of physiology |
Ort Quelle: | Hoboken, NJ : Wiley-Blackwell, 1878 |
Jahr Quelle: | 1993 |
Band/Heft Quelle: | 464(1993), 1, Seite 121-130 |
ISSN Quelle: | 1469-7793 |
Abstract: | 1. The feedback control of arterial blood pressure by the kidney in the range of hours was investigated in resting, conscious foxhounds. 2. A servo-control device (connected to an aortic occlusive cuff implanted above both renal arteries) was used to maintain a constant pressure difference of 20 mmHg between aortic pressure measured proximal (mean arterial blood pressure: MAP) and distal (renal artery pressure: RAP) to the aortic cuff. 3. Protocol 1 (n = 6) served as a 4 h time control without intervention, protocol 2 (n = 6) consisted of three periods: after a control of 20 min duration, the servo-control device was activated for 180 min; this was followed by a recovery period of 40 min. Protocol 3 (n = 6) was as protocol 2, but during converting-enzyme inhibition. 4. Servo-control increased plasma renin activity (PRA) transiently from 0.5 ng angiotensin I (AI) ml-1 h-1 to a peak value of 2.4 ng AI ml-1 h-1, subsequently both RAP and MAP rose to reach a new steady state. During this increase in RAP, PRA declined to 1.4 ng AI ml-1 h-1. 5. On average, the compensation of the pressure decrease sensed by the kidney amounted to 63% of the error signal (closed-loop gain of 0.63 +/- 0.1). 6. Converting-enzyme inhibition reduced this closed-loop gain significantly (protocol 2 vs. protocol 3, 0.63 +/- 0.1 vs. 0.15 +/- 0.1; P < 0.05). 7. It is concluded, that the kidney plays an important role in medium-term blood pressure regulation, most probably via the renin-angiotensin system. |
DOI: | doi:10.1113/jphysiol.1993.sp019626 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1113/jphysiol.1993.sp019626 |
| Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1113/jphysiol.1993.sp019626 |
| DOI: https://doi.org/10.1113/jphysiol.1993.sp019626 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1910825050 |
Verknüpfungen: | → Zeitschrift |
¬The¬ role of the kidney in canine blood pressure control / Persson, Pontus B. [VerfasserIn]; 01 May 1993 (Online-Ressource)