Spatially fractionated radiation therapy

• Verfasst von: Prezado, Yolanda [VerfasserIn]
• Verfasst von: Grams, Michael [VerfasserIn]
• Verfasst von: Jouglar, Emmanuel [VerfasserIn]
• Verfasst von: Martínez-Rovira, Immaculada [VerfasserIn]
• Verfasst von: Ortiz, Ramon [VerfasserIn]
• Verfasst von: Seco, Joao [VerfasserIn]
• Verfasst von: Chang, Sha [VerfasserIn]
• Titel: Spatially fractionated radiation therapy
• Titelzusatz: a critical review on current status of clinical and preclinical studies and knowledge gaps
• Verf.angabe: Yolanda Prezado, Michael Grams, Emmanuel Jouglar, Immaculada Martínez-Rovira, Ramon Ortiz, Joao Seco and Sha Chang
• E-Jahr: 2024
• Jahr: 10 May 2024
• Umfang: 22 S.
• Fussnoten: Gesehen am 05.12.2024
• Titel Quelle: Enthalten in: Physics in medicine and biology
• Ort Quelle: Bristol : IOP Publ., 1956
• Jahr Quelle: 2024
• Band/Heft Quelle: 69(2024), 10, Artikel-ID 10TR02, Seite 10TR02-1-10TR02-22
• ISSN Quelle: 1361-6560
• DOI: doi:10.1088/1361-6560/ad4192
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1910960209

Abstract

Spatially fractionated radiation therapy (SFRT) is a therapeutic approach with the potential to disrupt the classical paradigms of conventional radiation therapy. The high spatial dose modulation in SFRT activates distinct radiobiological mechanisms which lead to a remarkable increase in normal tissue tolerances. Several decades of clinical use and numerous preclinical experiments suggest that SFRT has the potential to increase the therapeutic index, especially in bulky and radioresistant tumors. To unleash the full potential of SFRT a deeper understanding of the underlying biology and its relationship with the complex dosimetry of SFRT is needed. This review provides a critical analysis of the field, discussing not only the main clinical and preclinical findings but also analyzing the main knowledge gaps in a holistic way.