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Verfasst von:Hansford, Jordan R. [VerfasserIn]   i
 Das, Anirban [VerfasserIn]   i
 McGee, Rose B. [VerfasserIn]   i
 Nakano, Yoshiko [VerfasserIn]   i
 Brzezinski, Jack [VerfasserIn]   i
 Scollon, Sarah R. [VerfasserIn]   i
 Rednam, Surya P. [VerfasserIn]   i
 Schienda, Jaclyn [VerfasserIn]   i
 Michaeli, Orli [VerfasserIn]   i
 Kim, Sun Young [VerfasserIn]   i
 Greer, Mary-Louise C. [VerfasserIn]   i
 Weksberg, Rosanna [VerfasserIn]   i
 Stewart, Douglas R. [VerfasserIn]   i
 Foulkes, William D. [VerfasserIn]   i
 Tabori, Uri [VerfasserIn]   i
 Pajtler, Kristian Wilfried [VerfasserIn]   i
 Pfister, Stefan [VerfasserIn]   i
 Brodeur, Garrett M. [VerfasserIn]   i
 Kamihara, Junne [VerfasserIn]   i
Titel:Update on cancer predisposition syndromes and surveillance guidelines for childhood brain tumors
Verf.angabe:Jordan R. Hansford, Anirban Das, Rose B. McGee, Yoshiko Nakano, Jack Brzezinski, Sarah R. Scollon, Surya P. Rednam, Jaclyn Schienda, Orli Michaeli, Sun Young Kim, Mary-Louise C. Greer, Rosanna Weksberg, Douglas R. Stewart, William D. Foulkes, Uri Tabori, Kristian W. Pajtler, Stefan M. Pfister, Garrett M. Brodeur, and Junne Kamihara
E-Jahr:2024
Jahr:April 4, 2024
Umfang:8 S.
Fussnoten:Gesehen am 05.12.2024
Titel Quelle:Enthalten in: Clinical cancer research
Ort Quelle:Philadelphia, Pa. [u.a.] : AACR, 1995
Jahr Quelle:2024
Band/Heft Quelle:30(2024), 11 vom: Juni, Seite 2342-2350
ISSN Quelle:1557-3265
Abstract:Tumors of the central nervous system (CNS) comprise the second most common group of neoplasms in childhood. The incidence of germline predisposition among children with brain tumors continues to grow as our knowledge on disease etiology increases. Some children with brain tumors may present with nonmalignant phenotypic features of specific syndromes (e.g., nevoid basal cell carcinoma syndrome, neurofibromatosis type 1 and type 2, DICER1 syndrome, and constitutional mismatch-repair deficiency), while others may present with a strong family history of cancer (e.g., Li-Fraumeni syndrome) or with a rare tumor commonly found in the context of germline predisposition (e.g., rhabdoid tumor predisposition syndrome). Approximately 50% of patients with a brain tumor may be the first in a family identified to have a predisposition. The past decade has witnessed a rapid expansion in our molecular understanding of CNS tumors. A significant proportion of CNS tumors are now well characterized and known to harbor specific genetic changes that can be found in the germline. Additional novel predisposition syndromes are also being described. Identification of these germline syndromes in individual patients has not only enabled cascade testing of family members and early tumor surveillance but also increasingly affected cancer management in those patients. Therefore, the AACR Cancer Predisposition Working Group chose to highlight these advances in CNS tumor predisposition and summarize and/or generate surveillance recommendations for established and more recently emerging pediatric brain tumor predisposition syndromes.
DOI:doi:10.1158/1078-0432.CCR-23-4033
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1158/1078-0432.CCR-23-4033
 DOI: https://doi.org/10.1158/1078-0432.CCR-23-4033
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1910967823
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