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| Verfasst von: | Swanton, Charles [VerfasserIn]  |
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| | Bernard, Elsa [VerfasserIn] |
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| | Abbosh, Chris [VerfasserIn] |
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| | André, Fabrice [VerfasserIn] |
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| | Auwerx, Johan [VerfasserIn] |
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| | Balmain, Allan [VerfasserIn] |
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| | Bar-Sagi, Dafna [VerfasserIn] |
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| | Bernards, René [VerfasserIn] |
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| | Bullman, Susan [VerfasserIn] |
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| | DeGregori, James [VerfasserIn] |
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| | Elliott, Catherine [VerfasserIn] |
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| | Erez, Ayelet [VerfasserIn] |
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| | Evan, Gerard [VerfasserIn] |
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| | Febbraio, Mark A. [VerfasserIn] |
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| | Hidalgo, Andrés [VerfasserIn] |
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| | Jamal-Hanjani, Mariam [VerfasserIn] |
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| | Joyce, Johanna A. [VerfasserIn] |
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| | Kaiser, Matthew [VerfasserIn] |
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| | Lamia, Katja [VerfasserIn] |
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| | Locasale, Jason W. [VerfasserIn] |
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| | Loi, Sherene [VerfasserIn] |
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| | Malanchi, Ilaria [VerfasserIn] |
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| | Merad, Miriam [VerfasserIn] |
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| | Musgrave, Kathryn [VerfasserIn] |
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| | Patel, Ketan J. [VerfasserIn] |
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| | Quezada, Sergio [VerfasserIn] |
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| | Wargo, Jennifer A. [VerfasserIn] |
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| | Weeraratna, Ashani [VerfasserIn] |
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| | White, Eileen [VerfasserIn] |
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| | Winkler, Frank [VerfasserIn] |
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| | Wood, John N. [VerfasserIn] |
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| | Vousden, Karen H. [VerfasserIn] |
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| | Hanahan, Douglas [VerfasserIn] |
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| Titel: | Embracing cancer complexity |
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| Titelzusatz: | hallmarks of systemic disease |
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| Verf.angabe: | Charles Swanton, Elsa Bernard, Chris Abbosh, Fabrice André, Johan Auwerx, Allan Balmain, Dafna Bar-Sagi, René Bernards, Susan Bullman, James DeGregori, Catherine Elliott, Ayelet Erez, Gerard Evan, Mark A. Febbraio, Andrés Hidalgo, Mariam Jamal-Hanjani, Johanna A. Joyce, Matthew Kaiser, Katja Lamia, Jason W. Locasale, Sherene Loi, Ilaria Malanchi, Miriam Merad, Kathryn Musgrave, Ketan J. Patel, Sergio Quezada, Jennifer A. Wargo, Ashani Weeraratna, Eileen White, Frank Winkler, John N. Wood, Karen H. Vousden, and Douglas Hanahan |
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| E-Jahr: | 2024 |
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| Jahr: | 28 March 2024 |
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| Umfang: | 28 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 06.12.2024 |
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| Titel Quelle: | Enthalten in: Cell |
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| Ort Quelle: | [Cambridge, Mass.] : Cell Press, 1974 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 187(2024), 7 vom: März, Seite 1589-1616 |
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| ISSN Quelle: | 1097-4172 |
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| Abstract: | The last 50 years have witnessed extraordinary developments in understanding mechanisms of carcinogenesis, synthesized as the hallmarks of cancer. Despite this logical framework, our understanding of the molecular basis of systemic manifestations and the underlying causes of cancer-related death remains incomplete. Looking forward, elucidating how tumors interact with distant organs and how multifaceted environmental and physiological parameters impinge on tumors and their hosts will be crucial for advances in preventing and more effectively treating human cancers. In this perspective, we discuss complexities of cancer as a systemic disease, including tumor initiation and promotion, tumor micro- and immune macro-environments, aging, metabolism and obesity, cancer cachexia, circadian rhythms, nervous system interactions, tumor-related thrombosis, and the microbiome. Model systems incorporating human genetic variation will be essential to decipher the mechanistic basis of these phenomena and unravel gene-environment interactions, providing a modern synthesis of molecular oncology that is primed to prevent cancers and improve patient quality of life and cancer outcomes. |
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| DOI: | doi:10.1016/j.cell.2024.02.009 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.cell.2024.02.009 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0092867424001752 |
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| | DOI: https://doi.org/10.1016/j.cell.2024.02.009 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1910984620 |
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| Verknüpfungen: | → Zeitschrift |
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Embracing cancer complexity / Swanton, Charles [VerfasserIn]; 28 March 2024 (Online-Ressource)
