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Verfasst von:Overbeek, Kasper A. [VerfasserIn]   i
 Poulsen, Jakob L. [VerfasserIn]   i
 Lanzillotta, Marco [VerfasserIn]   i
 Vinge-Holmquist, Olof [VerfasserIn]   i
 Macinga, Peter [VerfasserIn]   i
 Demirci, A. Fatih [VerfasserIn]   i
 Sindhunata, Daniko P. [VerfasserIn]   i
 Backhus, Johanna [VerfasserIn]   i
 Algül, Hana [VerfasserIn]   i
 Buijs, Jorie [VerfasserIn]   i
 Levy, Philippe [VerfasserIn]   i
 Kiriukova, Mariia [VerfasserIn]   i
 Goni, Elisabetta [VerfasserIn]   i
 Hollenbach, Marcus [VerfasserIn]   i
 Miksch, Rainer C. [VerfasserIn]   i
 Kunovsky, Lumir [VerfasserIn]   i
 Vujasinovic, Miroslav [VerfasserIn]   i
 Nikolic, Sara [VerfasserIn]   i
 Dickerson, Luke [VerfasserIn]   i
 Hirth, Michael [VerfasserIn]   i
 Neurath, Markus F. [VerfasserIn]   i
 Zumblick, Malte [VerfasserIn]   i
 Vila, Josephine [VerfasserIn]   i
 Jalal, Mustafa [VerfasserIn]   i
 Beyer, Georg [VerfasserIn]   i
 Frost, Fabian [VerfasserIn]   i
 Carrara, Silvia [VerfasserIn]   i
 Kala, Zdenek [VerfasserIn]   i
 Jabandziev, Petr [VerfasserIn]   i
 Sisman, Gurhan [VerfasserIn]   i
 Akyuz, Filiz [VerfasserIn]   i
 Capurso, Gabriele [VerfasserIn]   i
 Falconi, Massimo [VerfasserIn]   i
 Arlt, Alexander [VerfasserIn]   i
 Vleggaar, Frank P. [VerfasserIn]   i
 Barresi, Luca [VerfasserIn]   i
 Greenhalf, Bill [VerfasserIn]   i
 Czakó, László [VerfasserIn]   i
 Hegyi, Peter [VerfasserIn]   i
 Hopper, Andrew [VerfasserIn]   i
 Nayar, Manu K. [VerfasserIn]   i
 Gress, Thomas M. [VerfasserIn]   i
 Vitali, Francesco [VerfasserIn]   i
 Schneider, Alexander [VerfasserIn]   i
 Halloran, Chris M. [VerfasserIn]   i
 Trna, Jan [VerfasserIn]   i
 Okhlobystin, Alexey V. [VerfasserIn]   i
 Dagna, Lorenzo [VerfasserIn]   i
 Cahen, Djuna L. [VerfasserIn]   i
 Bordin, Dmitry [VerfasserIn]   i
 Rebours, Vinciane [VerfasserIn]   i
 Mayerle, Julia [VerfasserIn]   i
 Kahraman, Alisan [VerfasserIn]   i
 Rasch, Sebastian [VerfasserIn]   i
 Culver, Emma [VerfasserIn]   i
 Kleger, Alexander [VerfasserIn]   i
 Martínez-Moneo, Emma [VerfasserIn]   i
 Røkke, Ola [VerfasserIn]   i
 Hucl, Tomas [VerfasserIn]   i
 Olesen, Søren S. [VerfasserIn]   i
 Bruno, Marco J. [VerfasserIn]   i
 Della-Torre, Emanuel [VerfasserIn]   i
 Beuers, Ulrich [VerfasserIn]   i
 Löhr, J. -Matthias [VerfasserIn]   i
 Rosendahl, Jonas [VerfasserIn]   i
Titel:Type 1 autoimmune pancreatitis in Europe
Titelzusatz:clinical profile and response to treatment
Verf.angabe:Kasper A. Overbeek, Jakob L. Poulsen, Marco Lanzillotta, Olof Vinge-Holmquist, Peter Macinga, A. Fatih Demirci, Daniko P. Sindhunata, Johanna Backhus, Hana Algül, Jorie Buijs, Philippe Levy, Mariia Kiriukova, Elisabetta Goni, Marcus Hollenbach, Rainer C. Miksch, Lumir Kunovsky, Miroslav Vujasinovic, Sara Nikolic, Luke Dickerson, Michael Hirth, Markus F. Neurath, Malte Zumblick, Josephine Vila, Mustafa Jalal, Georg Beyer, Fabian Frost, Silvia Carrara, Zdenek Kala, Petr Jabandziev, Gurhan Sisman, Filiz Akyuz, Gabriele Capurso, Massimo Falconi, Alexander Arlt, Frank P. Vleggaar, Luca Barresi, Bill Greenhalf, László Czakó, Peter Hegyi, Andrew Hopper, Manu K. Nayar, Thomas M. Gress, Francesco Vitali, Alexander Schneider, Chris M. Halloran, Jan Trna, Alexey V. Okhlobystin, Lorenzo Dagna, Djuna L. Cahen, Dmitry Bordin, Vinciane Rebours, Julia Mayerle, Alisan Kahraman, Sebastian Rasch, Emma Culver, Alexander Kleger, Emma Martínez-Moneo, Ola Røkke, Tomas Hucl, Søren S. Olesen, Marco J. Bruno, Emanuel Della-Torre, Ulrich Beuers, J.-Matthias Löhr, and Jonas Rosendahl
E-Jahr:2024
Jahr:5 January 2024
Umfang:21 S.
Illustrationen:Diagramme
Fussnoten:Online verfügbar: 5. Januar 2024, Artikelversion: 23. April 2024 ; Gesehen am 09.12.2024
Titel Quelle:Enthalten in: Clinical gastroenterology and hepatology
Ort Quelle:New York, NY : Elsevier Science, 2003
Jahr Quelle:2024
Band/Heft Quelle:22(2024), 5 vom: Mai, Seite 994-1004, 1004.e1-1004.e10
ISSN Quelle:1542-7714
Abstract:Background & Aims - Autoimmune pancreatitis (AIP) is an immune-mediated disease of the pancreas with distinct pathophysiology and manifestations. Our aims were to characterize type 1 AIP in a large pan-European cohort and study the effectiveness of current treatment regimens. - Methods - We retrospectively analyzed adults diagnosed since 2005 with type 1 or not-otherwise-specified AIP in 42 European university hospitals. Type 1 AIP was uniformly diagnosed using specific diagnostic criteria. Patients with type 2 AIP and those who had undergone pancreatic surgery were excluded. The primary end point was complete remission, defined as the absence of clinical symptoms and resolution of the index radiologic pancreatic abnormalities attributed to AIP. - Results - We included 735 individuals with AIP (69% male; median age, 57 years; 85% White). Steroid treatment was started in 634 patients, of whom 9 (1%) were lost to follow-up. The remaining 625 had a 79% (496/625) complete, 18% (111/625) partial, and 97% (607/625) cumulative remission rate, whereas 3% (18/625) did not achieve remission. No treatment was given in 95 patients, who had a 61% complete (58/95), 19% partial (18/95), and 80% cumulative (76/95) spontaneous remission rate. Higher (≥0.4 mg/kg/day) corticosteroid doses were no more effective than lower (<0.4 mg/kg/day) doses (odds ratio, 0.428; 95% confidence interval, 0.054-3.387) and neither was a starting dose duration >2 weeks (odds ratio, 0.908; 95% confidence interval, 0.818-1.009). Elevated IgG4 levels were independently associated with a decreased chance of complete remission (odds ratio, 0.639; 95% confidence interval, 0.427-0.955). Relapse occurred in 30% of patients. Relapses within 6 months of remission induction were independent of the steroid-tapering duration, induction treatment duration, and total cumulative dose. - Conclusions - Patients with type 1 AIP and elevated IgG4 level may need closer monitoring. For remission induction, a starting dose of 0.4 mg/kg/day for 2 weeks followed by a short taper period seems effective. This study provides no evidence to support more aggressive regimens.
DOI:doi:10.1016/j.cgh.2023.12.010
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1016/j.cgh.2023.12.010
 kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S154235652301042X
 DOI: https://doi.org/10.1016/j.cgh.2023.12.010
 DOI: https://doi.org/10.25673/116452
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Autoimmune Pancreatitis
 IgG4-Related Disease
 IgG4-Related Pancreatitis
K10plus-PPN:1883689880
Verknüpfungen:→ Zeitschrift

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