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Status: Bibliographieeintrag

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Verfasst von:Khorani, Karam [VerfasserIn]   i
 Burkart, Sebastian [VerfasserIn]   i
 Weusthof, Christopher [VerfasserIn]   i
 Han, Rui [VerfasserIn]   i
 Liang, Siyuan [VerfasserIn]   i
 Stögbauer, Fabian [VerfasserIn]   i
 Heß, Jochen [VerfasserIn]   i
Titel:Context-dependent regulation of peripheral nerve abundance by the PI3K pathway in the tumor microenvironment of head and neck squamous cell carcinoma
Verf.angabe:Karam Khorani, Sebastian Burkart, Christopher Weusthof, Rui Han, Siyuan Liang, Fabian Stögbauer and Jochen Hess
E-Jahr:2024
Jahr:14 June 2024
Umfang:16 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 09.12.2024
Titel Quelle:Enthalten in: Cells
Ort Quelle:Basel : MDPI, 2012
Jahr Quelle:2024
Band/Heft Quelle:13(2024), 12, Artikel-ID 1033, Seite 1-16
ISSN Quelle:2073-4409
Abstract:Recent studies have highlighted neurons and their associated Schwann cells (SCs) as key regulators of cancer development. However, the mode of their interaction with tumor cells or other components of the tumor microenvironment (TME) remains elusive. We established an SC-related 43-gene set as a surrogate for peripheral nerves in the TME. Head and neck squamous cell carcinoma (HNSCC) from The Cancer Genome Atlas (TCGA) were classified into low, intermediate and high SC score groups based on the expression of this gene set. Perineural invasion (PNI) and TGF-β signaling were hallmarks of SChigh tumors, whereas SClow tumors were enriched for HPV16-positive OPSCC and higher PI3K-MTOR activity. The latter activity was partially explained by a higher frequency of PTEN mutation and PIK3CA copy number gain. The inverse association between PI3K-MTOR activity and peripheral nerve abundance was context-dependent and influenced by the TP53 mutation status. An in silico drug screening approach highlighted the potential vulnerabilities of HNSCC with variable SC scores and predicted a higher sensitivity of SClow tumors to DNA topoisomerase inhibitors. In conclusion, we have established a tool for assessing peripheral nerve abundance in the TME and provided new clinical and biological insights into their regulation. This knowledge may pave the way for new therapeutic strategies and impart proof of concept in appropriate preclinical models.
DOI:doi:10.3390/cells13121033
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.3390/cells13121033
 DOI: https://doi.org/10.3390/cells13121033
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:axonogenesis
 cancer-neuron interaction
 Class I Phosphatidylinositol 3-Kinases
 Gene Expression Regulation, Neoplastic
 Head and Neck Neoplasms
 head and neck squamous cell carcinoma
 human papillomavirus
 Humans
 Mutation
 neurogenesis
 perineural invasion
 Peripheral Nerves
 Phosphatidylinositol 3-Kinases
 PTEN Phosphohydrolase
 Schwann cells
 Schwann Cells
 Signal Transduction
 Squamous Cell Carcinoma of Head and Neck
 TOR Serine-Threonine Kinases
 tumor microenvironment
 Tumor Microenvironment
 Tumor Suppressor Protein p53
K10plus-PPN:1911249371
Verknüpfungen:→ Zeitschrift

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